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Gujarat Technological University 2009-1st Sem B.Pharm Pharmacy - Question Paper

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Pharmacy 1st Semester Paper 2009

GUJARAT TECHNOLOGICAL UNIVERSITY

B. Pharmacy Sem-I Examination January 2010

Seat No. Enrolment No.

Subject code: 210001 Subject Name: APHE-I

Date: 01 / 01 / 2010 Time: 12.00 - 3.00 pm

Instructions: Total Marks: 80

1. Attempt any five questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) Define: Cell. Describe the structure of Cell membrane with 06 appropriate diagram. Give functions of Cell membrane.

(c) Write composition and functions of Lymph. 0 5

Q.2 (a) Define and classify Allergy. Discuss features of various types of 06 Allergy.

(c) Discuss different types of Synovial joints with appropriate examples 05 for each type.

Q.3 (a) Differentiate between (i) Active and Passive transport 0 6

(ii) Skeletal and Cardiac muscle

(c) Write about composition of bone and functions of skeleton. 05

Q.4 (a) Discuss functions of Blood. 06

(b) Describe changes during different phases of cell cycle. Draw 05 suitable diagrams.

(c) Classify Eicosanoids. Write a note on Prostaglandins. 05

Q.5 (a) Explain Protein synthesis with suitable diagrams. 06

(c) Describe basic mechanism of Inflammation. 05

Q. 6 (a) Give functions of followings: 06

(i) Mitochondria (ii) Platelets (iii) Gastric juice

(b) Write biosynthesis of Serotonin (5-HT).What are the actions of 5- 05 HT on blood vessels?

(c) Describe structure of Neuron with a labeled diagram. Write about 05 different types of Neuron.

Q.7 (a) Define the following terms: 06

(i) Osteoporosis (ii) Inflammation (iii) Hemophilia (iv) Tissue (v) Lymphosarcoma (iv) Cartilaginous joints

(b) Explain steps of Erythropoiesis. Give normal life span, shape and 05 size of RBC.

Subject code: 210002 Subject Name: Basic Computer Applications Date: 02 / 01 / 2010 Time: 12.00 - 3.00 pm

Instructions: Total Marks: 80

1. Attempt any five questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Write Sequence of dos commands as well as windows steps to create 06

Q.1 (a)

(b)

(c)

1. Any folder or directory in C: drive.

2. Any file within the folder or directory created in above step.

Explain Computer Organization and Storage Devices. 05

What is OS? Give types and explain characteristics. 05

Q.2 (a) Give Answers of following Questions. 06

1. Find x.

(28)10 = (x)2 (48)10 = (x)2 (1001)2 = (x)10

2. Write short note on computer Viruses.

(b) What is the benefit of creating slideshow presentations explain with 05 an example.

(c) What is ADOBE ACROBAT reader? Explain the usage. 05

Q.3 (a) What is Ms Access? Explain different components of database. 06

(b) What is email and email components? What is the usage of 05 Outlook?

(c) What is internet? How internet works? 05

Q.4 (a) How computer Networks are created? Why? 06

(c) What is the usage of word? Explain. 05

Q.5 (a) Answers the following. 06

1. What is Autocorrect and Auto-text?

2. What is paragraph formatting? Explain.

3. Give any three table operations.

(c) Explain page setup and print preview. 05

Q. 6 (a) 1. Explain any five library functions in Excel. 06

2. What is range in Excel. Give its type with example.

(c) What is sorting? Give the example and explain. 05

Q. 7 (a) Give following Answers. 06

1. Explain Website, Webpage, Home-Page.

2. What is a search Engine? Give Example.

3. What is the function of modem?

GUJARAT TECHNOLOGICAL UNIVERSITY

B. Pharm Sem-I Examination January 2010

Subject code: 210003 Subject Name: Pharmaceutical chemistry - I Date: 04 / 01 / 2010 Time: 12.00 - 3.00 pm

Instructions: Total Marks: 80

1. Attempt any five questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) What do you mean by impurities? Explain the importance of limit 06 test in Pharmaceutical Preparation. Explain the principle of limit test for Iron.

(b) Define following terms with illustration 05 1. Respiratory stimulant 2. Sedative 3. Suspending agent

4. Cathartics 5. Pharmaceutical aids

(c) Give the synonyms and uses of following 05 1. Common salt 2. Chlorinated lime 3. Baking soda

4. Rochelle salt 5. Slaked lime

Q.2 (a) Discuss the factors affecting selection of Pharmaceutical buffers and 06 name any two physiological buffers and two analytical buffers.

(b) Write Assay Principle and chemical reaction of following 06 1. Zinc oxide 2. Boric acid 3. Ammonium chloride

(c) What is meant by 04 1. Official Compound 2. Pharmacopoeia 3. Buffer solution

4. Hard water

Q.3 (a) Classify antimicrobial agents with example and discuss its 06

mechanism of action

(b) Write the storage condition 05

1. Oxygen 2. Phosphoric acid 3. Silver Nitrate 4. Iodine

(c) Write a note on 05

1. Dental Products 2. Antidotes

Q.4 (a) Comment on following 06

1. Manganese dioxide is used in preparation of iodine from kelp.

2. Glycerin is added in assay of Boric acid.

3. Aqueous Ammonia is added in limit test of lead

(b) Classify following 05 1. Saline cathartics 2. Antioxidants

(c) Explain the following terms 05 1. Astringent 2. Emetics 3 Hygroscopic

4. Deliquescence 5. Efflorescence

Q.5 (a) Distinguish between 06

1. Poison and Antidote

2. Hypochlorhydria and Hyperchlorhydria

3. Hypokalemia and Hyperkalemia

(b) Name the compounds which is used as 05

1. Anticoagulant 2. Expectorant 3. General anesthetic

4. Heamatinic 5. Fire extinguisher

(c) Discuss 05

1. Electrolyte used for replacement therapy

2. Essential ions

Write Preparation of following

Q. 6 (a)

(b) (c) (a)

06

05

1. Sodium thiosulphate 2. Sodium hydroxide

3. Calcium gluconate

Give preparation of 5% w/v aqueous solution of iodine. Give the reasons for the reagents used in preparation.

Enlist the sources of the impurities in Pharmaceuticals and discuss the manufacturing hazards as source of impurity.

What are Radiopharmaceuticals ? Give uses of Iron [⁵⁹Fe], Na ¹³¹I

57

and Cynocobalamine [ Co].

Write a note on purified water and water for injection

What are ideal requirement of antacids. Give preparation and uses of

any one antacid.

131_T

Q.7

06

05

(b)

(c)

2

Seat No. Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY B. Pharmacy Sem-I Examination January 2010 Subject code: 210004 Subject Name: Pharmaceutical Engineering

Date: 05 / 01 / 2010 Time: 12.00 - 3.00 pm

Instructions: Total Marks: 80

1. Attempt any five questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) What is the principle of working of Rota meters? Give their general 06 design and working.

(c) What is Reynolds number? Show how it is dimensionless.What is its 05 significance in fluid flow?

Q.2 (a) Discuss various factors affecting selection of material of Pharmaceutical 06 plant construction.

(c) Discuss advantages and limitations of different kind of plastics used in 05 Pharmaceutical industry.

Q.3 (a) Discuss Daltons law, Amagats law and their corollary.

06

05

(b) Discuss dimensional analysis, its advantages and disadvantages.

(c) A salt solution originally contains 4% by weight NaCl in water is evaporated to 5% by weight NaCl. (NaCl is a tie substance.)

(a) What percentage of water evaporated? (b)What is the reduction in original solution?

Q.4 (a) What is thermal radiation? Explain the concept of Black body and Gray 06 body in thermal radiation.

(a)

(b) (c)

(a)

(b) (c)

(a)

(b)

Q.5

Q. 6

Q. 7

What are differences between Pipe and Tubings? 05

Describe Belt conveyer. 05

Discuss the principle involved in Mass transfer. Enumerate unit 06 operations in which mass transfer operation is involved.

Define the following terms, (i) Absolute pressure (ii) Gauge pressure 05 (iii) Calorie (iv) British thermal unit (v) Absolute Zero temperature.

Discuss the procedure of conversion of units. Express 1.80 gram/cubic 05 cm as pound/gallon

What is a Manometer? Derive equation applicable for simple 06 manometer.

Write Short Notes : (Any Two) 05

(i) Arithmatic mean temperature and Logarithmic mean temperature

(ii) Different types of Graphs (iii) Colour code for piping system

A mercury manometer is connected across a ventury meter.The pressure 05 on up stream - side (Pi) is 0.5 kg/cm² gauge. The manometer reading (AP) is 70mm.Hg.The fluid flowing is water. Calculate pressure at throat (P2)

Density Water - 1 gm/cm³ Density Hg. - 13.6 gm/cm³.

(c)

Seat No. Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B. Pharmacy Sem-I Examination January 2010 Subject code: 210005 Subject Name: Pharmaceutics I

Date: 06 / 01 / 2010 Time: 12.00 - 3.00 pm

Instructions: Total Marks: 80

1. Attempt any five questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

Q.1 (a) Comment: Viscosity of slurry is an important factor in rate of filtration.

(b) Discuss the various mechanisms of filtration process.

(c) Describe rotary drum filter with diagram.

(d) Calculate the compressibility exponent of a cake based on following experimental filtration data:

Pressure difference (lbf/inch )	Specific cake resistance [(lbf)(h))/(lb)(ft)]
2	3.1
5	3.9

Q.2 (a) Explain: Centrifugal effect with equation.

(b) Write note on Metafilter.

(c) Describe contineous centrifuge with diagram.

(d) Discuss the principle of tubular bowl centrifuge with diagram.

Q.3 (a) Comment: Evaporation under reduced pressure should be used with caution.

(b) Discuss Duhrings rule and Raoults law.

(c) Describe short tube evaporator with diagram.

(d) Discuss principle, advantages and disadvantages of film evaporators.

Q.4 (a) Explain: HETP and HTU.

(b) Differentiate: Evaporation and Distillation.

(c) Describe the steam distillation process.

(d) A 100 mole of liquid mixture containing 0.20 and 0.80 mole fraction of components A and B, respectively was subjected to simple batch distillation. What will be the liquid composition after 8 mole of component A has been removed with the vapors? Assume a_ab as constant at 1.414.

Q.5 (a) Explain: CMC and EMC.

(b) Describe fluidized bad dryer with diagram.

(c) Discuss the process of spray drying.

(d) The wet solid containing 3 lb of water/lb of dry solid and with a density of 50 lb/ft³ was subjected to a drying using 4 ft long and 3 ft wide trays with wet solid depth of

2 inch. Calculate the number of trays required to obtain 3000 lb of a product containing 1 lb of water/lb of dry solid.

Q. 6 (a) Explain: Humidification and dehumidification.

(b) Discuss applications of humidity control in pharmacy.

(c) Draw a labeled diagram of humidifier with essential components.

(d) Describe compression refrigeration cycle with diagram.

Q. 7 (a) Explain: Rectification and reflux ratio.

(b) Write note on azeotropic distillation.

(c) Describe mechanical hygrometers with diagram.

(d) Discuss principle, advantages and disadvantages of freeze drying.

Seat No:__Enrolment No:

GUJARAT TECHNOLOGICAL UNIVERSITY B. Pharmacy Sem-I Examination January-2010 Subject Code: 210006 Subject Name: Elementary (Remedial) Mathematics

Time: 12.00 - 3.00 pm

Date: 07 / 01 / 2010

Total Marks: 80

Instructions:

1. Attempt any five questions.

2. Make suitable assumptions whenever necessary.

3. Figures to the right indicate marks.

Q-1 (a) Give the general form of quadratic equation. Also show that if the 06

1

sum of the roots of the equation

x + a x + b c

product of the roots is -(a² + b²).

(b)

If a and ( are the roots of quadratic equation x² - px + q = 0 , then ⁰⁵

q

construct a quadratic equation whose roots are

and

p-a p-( Solve the simultaneous equations x + y = 8 and x² + 5x + y = 4.

(c)

05

Define symmetric and skew-symmetric matrix. Express the matrix

" 2 4 6"

A =8 10 12 as a sum of symmetric and skew-symmetric 14 16 18 matrix.

Solve the following system of equations using inverse of a matrix:

x + y + z = 3

2 x + y + z = 4 x + 2 y + 3z = 6

Evaluate the following determinant 1 + x 1 1

Q-2 (a)

06

(b)

05

(c)

05

1+y 1

1 1 + z

Q-3 (a) Define Mean and Standard deviation for grouped data. Calculate the 06 mean and standard deviation for the following table giving the age distribution of 542 members.

Age in years	20-30	30-40	40-50	50-60	60-70	70-80	80-90
No. of members	3	61	132	153	140	51	2

(b) The following distribution shows the days of confinement after 05 delivery for 25 patients._

Days of confinement	6	7	8	9	10
Number of patients	7	6	5	4	3

Find the mean, standard deviation.

The probability that an infection is cured by a particular antibiotic 05 drug within5 days is 0.75. Suppose four patients are treated by this antibiotic drug, then what is the probability that

^(c)

i. No patient is cured

ii. Exactly two patient are cured

iii. At least two patient are cured

Q-4 (a)

06

(b)

05

In a pharmaceutical factory, machine A and B manufacture 40% and 60% of the total output. Of this production of tablets, machine A and B produce 5% and 10% defective tablets. A tablet is picked at random and is found to be defective. What is the probability that the tablet was produced by the machine A?

The 3^rd term of an arithmetic progression (A.P) is 10 & its 10^th term is 31. Find the sum of first 25 terms of this A.P

1

(c) Find the constant term in the expansion of I x +-

x

1 3 n

If sina = 1= and cosB=and if 0 <a, B < , then prove that

V5 V10 2 ^F

Q-5 (a)

06

a+ B = .

4

(b) Find the equation of a straight line passing through the point of 05 intersection of the lines y = 2x + 1 and y=x+2 & which is parallel

to y = 4x + 7 .

(c) If log | ^a + ^b | = (log a + log b) then prove that a=b. 05

2

d ²y dx²

dy x-y dx

06

05

x~

x

Q-6 (a) If x = (a + bx) e^/x then prove that (b) Find y_n for y =

(x -1)( x - 2)

^(c) ( xy² + x) dx + (yx² + y) dy = 0

Q-7 (a) The rate at which bacteria multiply is proportional to the 06 instantaneous number present. If the original number doubles in 2 hours, in how many hours will it triple? dx

05

(b) Evaluate [,

xyj x +1

n/

/2

(c) Evaluate I = J (1 + cot x) ¹ dx.

05

0

2