Kerala University 2009 M.B.B.S Second Professional , PATHOLOGY ( – I) (Includes Lab Medicine and General Pathology) - Question Paper

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Second Professional M.B.B.S Degree Examination, June 2009 PATHOLOGY (Paper - I) (Includes Lab Medicine and General Pathology)

Time : 2 Hours    Max. Marks : 40

SECTION -A

I. Single best response type.

a)    Do not write anything on the question paper.

b)    Write your register number in the answer sheet provided.

c)    Select one most appropriate response and encircle the corresponding alphabet against each question number in the answer sheet provided.

1)    Tell tale sign of ageing is_pigment.

a) Melanin    b) Bile

c) Hemosiderin    d) Lipofuscin

2)    Basement membrane is composed of_Collagen

a) Type I    b) Type II

c) Type III    d) Type IV

3)    Fixative of choice for cytology

a) 10% formaline    b) 8% HNO3

c) 95% ethyl alcohol    d) Osmium tetroxide

4)    All are examples of free radicals EXCEPT

a) Ferrous ions    b) Transferrin

c) Glutathione Peroxidase    d) Ceruloplasmin

5)    Which of the following is a powerful chemoattractant ?

a) Thromboxane A₂    b) Nitric Oxide

c) Leucotriene B₄    d) Bradykinin

6)    All are antigen presenting cells EXCEPT

a) B cells    b) NK cells

c) CD8 T cells    d) Dendritic cells

7)    Which is NOT an example of Type II Hypersensitivity ?

a) Rheumatoid arthritis    b) Autoimmune hemolytic anemia

c) Myasthenia gravis    d) ABO incompatability

8)    All are features of autosomal dominant disorders EXCEPT

a) Onset of disease is late in life b) Variable expressivity

c) Variable penetrance d) Consanguinity (8xV2 =4 Marks) II. Match the following : A)    1) EDTA 2)    HEPARIN 3)    Sodium Citrate 1:4 4)    Sodium Citrate 1:9 B)    1) Amyloid 2) Lipid 3)    Calcium 4)    Iron

A)    Coagulation studies B)    Osmotic fragility C)    Peripheral Smear D)    ESR estimation E)    Coombs test A)    Vonkossa B)    Pearls C)    Sudan black D)    Congored E)    Alcian blue

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III. Draw and label :

1)    Tuberculous granuloma

2)    Oxalate crystals in urine.

IV.    Short answer question.    (1x4=4 Marks)

1)    What is Virchow triad ?

2)    What are Opsonins ? Give one example.

3)    Mention two difference between transudate and exudate.

4)    What is dystrophic calcification ? Give one example.

V.    Write short notes on :

1)    Sputum cytology

2)    Mitochondrial inheritance

3)    Acute transplant rejection reaction.    (3x2=6 Marks)

SECTION - B

VI.    30 year old female c/o fever, joint pain for a duration of 3 weeks. O/E butter fly rashes present on her face. Investigation revealed haematuria and massive proteinuria.

a)    What is your diagnosis ?

b)    Mention two serological test by which you can confirm the diagnosis.

c)    Mention two common cardiac lesions that can occur in the patient.

d)    Mention the characteristic microscopic finding seen in renal biopsy.

e)    Mention the usual hematological presentation in this condition.

f)    What is the usual cause of death in these patients ?

VII.    Short answer question.

a)    What is anaplasia ?

b)    What is double hit theory or Knudson hypothesis ?

c)    What is Pleiotropism? Give a suitable example.

d)    What is granulation tissue ?    (4x1=4 Marks)

VIII.    Write short notes on :

a)    Trephine biopsy

b)    Apoptosis

c)    Oncogenic Viruses    (3x2=6 Marks)

Attachment: kerala-university-2009-m-b-b-s-40307-1.pdf

Earning:   Approval pending.