Biju Patnaik University of Technology 2008-8th Sem B.Pharm Advanced Pharmaceutical Analysis - Question Paper
Time : 3 Hours
Answer Question No. 1 which is compulsory and any five from the rest.
The figures in the right-hand margin indicate marks.
1. Answer the following questions in brief :
2x10
(a) Write the principle of supercritical fluid chromatography.
(b) Write the applications of size exclusion chromatography.
(c) What is the colorimetric method used for the assay of Vitamin A ?
(d) Write the principle of ESR.
(e) What are the limitations of ESR ?
(f) What is the principle of X-ray fluorescence spectrometry ?
(g) Write briefly about PDAC reagent.
(h) What are the basic types of plastics used for closures ?
(i) Explain the principle behind the colorimetric method of determination of Aspirin.
(j) Mention the qualitative test for barbiturates.
(a) What is diffraction of X-rays ? 1
(b) Derive Braggs equation. 3
(c) Discuss briefly the instrumentation and applications of X-ray diffraction method.
6
3. Describe the principle and procedure involved in using PDAB reagent in drug analysis with suitable examples. 10
4. (a) Explain the principle involved in diazotiza-
tion. 5
(b) Describe the reagents used and procedure for the determination of sulfadiazine. 5
5. Explain the principle involved in the analysis of steroids. 10
6. (a) Describe the different types of glass and
rubber containers used for different dosage forms. 8
(b) Discuss hydrolytic resistance test for glass containers. 2
7. Describe the official quality control tests for parenteral products with their limits. 10
8. Explain the principle and procedure involved in the analysis of penicillins. 10
PH. E13 4 -C
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