M.Sc-M.Sc BioTechnology 2nd Sem BT - 25 : Bioinformatics(University of Pune, Pune-2013)

BIOTECHNOLOGY

BT - 25 : Bioinformatics

(2005 Pattern)

Time : 1½ Hours]                                                                                         [Max. Marks :40

Instructions to the candidates :

1)       Question Nos. 1 is compulsory. Out of the remaining attempt 2 questions.

2)       Neat diagrams must be drawn wherever necessary.

3)       Figures to the right indicate full marks.

Q1) What is sequence Alignment? Give full account of pairwise sequence alignment.

[10]

Q2) a)      Write in detail “Homology Based Gene Prediction”.                         [5]

b)       Write difference between Local & Global Alignment.                       [5]

c)       What is classification of protein? Explain with the help of CATH Topology.[5]

Q3) Write short notes on :                                                                                           [15]

a)       BLAST

b)       Gen Bank

c)       Pattern searching.

Q4) a)      Explain in detail Ab initio structure prediction of proteins. Give name of

the tools used in Ab initio prediction.                                                     [8]

b)       What is Entrez? Explain the information retrieval system by Entrez. [7]

Earning:   Approval pending.