M.Sc-M.Sc Bio Chemistry 3rd Sem BCH - 371 : Medical Biochemistry and Immunology(University of Pune, Pune-2013)

                                            M.Sc. (Semester - III)

                                                      BIOCHEMISTRY

SEAT No. :

[Total No. of Pages : 2

BCH - 371 : Medical Biochemistry and Immunology

(2008 & 2010 Pattern)

Time : 3 Hours]                                                                                                     [Max. Marks : 80

Instructions to the candidates:

1) All questions are compulsory.

2) Figures to the right indicate full marks.

3) Answers to the two sections should be written on separate answer books.

SECTION - I

(Medical Biochemistry)

Q1) Answer any three of the following:

a) Elaborate on Causative agents that lead to carcinogenesis.

b) Discuss the role of clotting factors involved in thrombus formation.

c) Explain the biochemical basis of sickle cell Anaemia.

d) Elaborate on the role of isoenzymes in the diagnosis of heart diseases.

Q2) Answer any three of the following:                                                                  [15]

a) Write the normal composition of CSF and list out two abnormal

components that are seen in CSF during pathological conditions.

b) Discuss the mechanism of action of streptomycin and Tetracycline.

c) Elaborate on types of Influenza.

d) Define the term analgesics. Give their mechanism of action with suitable

examples.

Q3) Write notes on any two of the following :                                                     [10]

a) Apoptosis.

b) Hydrolytic enzymes of lysosomes. c) LSD.

P.T.O.

SECTION - II

(Immunology)

Q4) Answer any three of the following:                                                                  [15]

a) Elaborate on primary and secondary lymphoid organs and their

significance with neat diagram.

b) List out different classes of antibodies and give their features.

c) Classify immunodiffusion techniques and elaborate on the procedure of

any one such technique.

d) Explain the principle procedure and application of western flotting.

Q5) Answer any three of the following:                                                                  [15]

a) Differentiate between the characteristic feature and production of

monoclonal and polyclonal antibodies.

b) Write note on blood group substances.

c) Elaborate on the mechanism of development of any one auto immune

disease.

d) Give the characteristics features of anaphylaxis.

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