M.Sc-M.Sc Bio Chemistry 3rd Sem BCH - 373 : Biochemical Toxicology(University of Pune, Pune-2013)

                                                            M.Sc. (Semester - III)

                                                                             BIOCHEMISTRY

SEAT No. :

[Total No. of Pages : 2

BCH - 373 : Biochemical Toxicology

(2008 & 2010 Pattern)

Time : 3 Hours]                                                                                                     [Max. Marks : 80

Instructions to the candidates:

1) All questions are compulsory.

2) Figures to right indicate full marks.

Q1) Answer any five of the following :                                                                   [20]

What does it mean by additive, synergistic, potentiation and antagonistic

effects?

Animal develops tolerance against the toxicants. Explain with suitable

examples.

How teratogenic potential of chemical is evaluated?

How soil and water pollutants are degraded?

What are the toxic effects of ozone and peroxyacetyl nitrate?

Give the biochemical reactions involved in parathion biotransformation.

Q2) Attempt any five of the following :                                                                  [20]

Give the forensic applications of toxicology.

Give the composition and adverse effects of lizard venom.

Explain the role Cytochrome P-450 in xenobiotic metabolism. Give the factors that affect the metal toxicity.

What is the fate of heavy metal lead in human body?

Explain the adverse effects caused by methanol and chloroform.

Reductive metabolism of xenobiotics catalyzed by Cytochrome P-450

leads to cellular injury. Explain.

P.T.O.

Q3) Answer any four of the following :                                                                  [20]

Give overall impact of chlorinated insecticides on ecosystem.

Compare the inhibition of acetylcholinesterase caused by organophosphrous

and carbamate insecticides.

Distinguish between venomous and poisonous animals.

Explain the mechanism of biotransformation catalyzed by

N-acetyltransferase.

What are the local toxic effects of organophosphrous insecticides. Explain the carcinogenicity of arsenic.

Q4) Give the pathogenesis and clinical manifestations of any four of the

following:                                                                                                                    [20]

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