M.B.B.S-M.B.B.S 2nd Year Pharmacology- Paper I(Kerala University of Health Sciences-2013)

Code: 201001 Reg. no.: …………………
Second Professional MBBS Degree Examinations, April 2013
Pharmacology- Paper I

Time: 3 Hours                                                                            Total Marks: 50

• Answer all questions

• Draw diagrams wherever necessary

Essays: (2x6=12)

1. A 24year old man is brought to the hospital with complaints of unconsciousness , sustained contractions (tonic) of all the body muscles followed by periods of muscle contraction alternating with periods of relaxations(clonic) lasting 1 to 2 minutes . Answer the following:
• What are the drugs that can be prescribed to this patient.
• Describe the pharmacokinetics and adverse effects of any one such drug.
• What is the treatment of status epilepticus. (2+3+1=6)
2. Classify diuretic agents. Describe the mechanism of action, uses and adverse effects of furosemide. (2+2+1+1=6)
Short notes: (5x3=15)
3. Calcium channel blockers
4. Drug treatment of anti cholinesterase poisoning
5. Kinetics of elimination
6. Halothane
7. Nicorandil
Answer briefly: (5x1=5)
8. Rationale of combining beta blockers with long acting nitrates
9. Clinical uses of prostaglandins
10. Mechanism of action of disulfiram
11. Flumazenil
12. Hofmann elimination
Name two drugs for: (8x1=8)
13. Drugs used in Myasthenia gravis
14. Uterine relaxants
15. Mast cell stabilizers
16. Mucolytics
17. Low molecular weight heparins
18. Anti platelet drugs
19. Drug induced parkinsonism
20. 5HT antagonists
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