M.Pharm-M.Pharm 3rd Year Medicinal Chemistry(Kerala University of Health Sciences-2014)

QP CODE:305326                                      Reg.No: ……………………..
Third Year Pharm D Degree Examinations - September 2014
Medicinal Chemistry

Time: 3 Hours                                                                                               Total Marks: 70

• Answer all Questions.

• Draw Diagrams wherever necessary.

Essays (3x10=30)

1. What are hypolipidemic agents and classify it with structures. Outline the synthesis
of benzafibrate and nicotinic acid
2. What are thiazide diuretics and mention the examples with structures. Explain the
structure activity relationship of it.
3. What are the diagnostic agents classify it with examples. Outline the synthesis of
any two of them
Short notes (8x5=40)
4. Explain any two electronic parameters of QSAR drug design.
5. Outline the mechanism of carrier linked pro drugs with special reference to
carboxylic acid moiety and carbonyl moiety
6. How will you carry out the combinatorial synthesis on solid support.
7. Classify anticancer agents and add a note on mechanism of action of alkylating
agents
8. Explain the synthesis of hexachlorophene and halazone.
9. Synthesis of propyl paraben and methyl paraben.
10. Explain the synthesis of any one second generation quinolones used as urinary
tract anti infective agents.
11. What are anti viral agents. Outline the synthesis of lamivudine.
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