M.Pharm-M.Pharm 3rd Year Medicinal Chemistry(Kerala University of Health Sciences-2014)

QP CODE:305326                                                   Reg.No: ……………………..
Third Year Pharm D Degree Supplementary Examinations - April 2014
Medicinal Chemistry

Time: 3 Hours                                                                                                        Total Marks: 70

• Answer all Questions.

• Draw Diagrams wherever necessary.

Essays (3x10=30)

1. Classify sulfonamides with examples. Explain crystalluria and mention the
synthesis of dapsone.
2. Enumerate the different classes of drugs acting on cardiovascular system with
suitable examples. Explain vasodilators with suitable examples and synthesis of
one vasodilator.
3. Define and classify antibiotics with examples. Add a note on SAR of amino
glycoside and tetracycline antibiotics.
Short notes (8x5=40)
4. Classify steroidal hormones. Explain the chemistry of steroids used as oral
contraceptives.
5. Explain mechanism of action of loop diuretics. Mention the synthetic route for
furosemide.
6. What are the factors to be considered for the development of new drug and explain
Hansch analysis.
7. Discuss the chemistry and mechanism of action of urinary tract anti infective
agents. Mention the synthetic route for any one of them.
8. Describe the chemistry and MOA of oral hypoglycemic agents with examples.
Discuss the synthetic route for tolbutamide.
9. Synthesis, MOA and uses for metronidazole & ethambutol
10. What are anti neoplastic agents. Explain the concept of anti metabolites used in
cancer chemotherapy and mention its advantages over other anti neoplastic
agents with examples.
11. Distinguish between antiseptic and disinfectant. Mention two examples and its
structure. Add a note on cationic surfactants.
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