B.Pharm-B.Pharm 2nd Year PHARMACEUTICAL CHEMISTRY III (2010 SCHEME)(Kerala University of Health Sciences-2014)

QP CODE:201006 (OLD SCHEME) Reg.No: ……………………..
Second Year B.Pharm Degree Supplementary Examinations - August 2014
PHARMACEUTICAL CHEMISTRY III (2010 SCHEME)
(Advanced Organic Chemistry)
Time: 3 Hours Total Marks: 100
• Answer all Questions.
• Write equations wherever necessary.
Essay (3x10=30)
1. How will you prepare an asymmetric compound by stereo-specific method. Add a
note on stereo-selective synthesis
2. Explain the structure, nomenclature, aromaticity and method of preparation of
quinolines
3. Describe in detail about the mechanism of Michael addition and Hofmann
rearrangement
Short notes (14x5=70)
4. Mention any five important reactions of anthracene
5. Define conformational analysis and elements of symmetry
6. Discuss the oxidation reactions involving perchloric acid and mercuric acetate
7. Explain the method of preparation of indole
8. Explain the structure and numbering of furan, oxepine, pyrazine, acridine and
phenanthrene
9. How will you determine the configuration of isomers.
10. Describe the reactivity of naphthalene
11. Mechanism involved in metal hydride reduction
12. Explain the preparation and reactions of phenothiazine
13. Stereochemistry of amines
14. Explain the various reactions of oxazole
15. Explain the mechanism of reactions involved in lead acetate and selenium oxide
16. Describe the structure and nomenclature of diazepine, dibenzazepine, quinalone and
quinazolone
17. Mention the various methods involved in the preparation of thiophene.
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