Kerala University of Health Sciences 2011 M.B.B.S First Professional s - Biochemistry - II tember - Question Paper

1st Professional MBBS Degree exams - September 2011

Biochemistry - Paper II

Time : 3hrs Max Marks: 50

. ans all ques.
. Draw diagrams wherever necessary

Essay:(Marks: 10)

1. define how protein is synthesized in body. Name and 2 inhibitors of protein biosynthesis. Add a note on post translational changes. (6+2+2=10)

explain the following: (Marks: 2x5=10)

2. Outline the degradation of heme. Add a note on fate of conjugated bilirubin in intestine.
3. Write briefly on storage and absorption of iron fron intestine.

Write short notes on: (Marks: 3x5=15)

4. What is gout? Mention the causes of primary gout.
5. What is the role of kidney in acid base regulation?
6. elaborate restriction endonucleases? elaborate their uses?
7. Write principle and application of polymerase chain reaction?
8. Write structure of IgG molecule and indicate its function?

Answere briefly: (Marks: 5x2=10)

9. Name the coenzyme forms of niacin and write important functions for every 1 of them.
10. Wilson's disease.
11. What is metabolic acidosis? provide 1 example of a disease associated with it.
12. provide 1 examples of detoxification by conjugation.
13. What is post hepatic jaundice? How is it diagnosed biochemically?

provide precise answers: (Marks: 5x1=5)

14. What is provitamin. provide 1 example.
15. Clinical features of rickets
16. provide 1 example for point mutation.
17. elaborate enzymes commonly used in ELISA Technique
18. Xeroderma pigmentosum is due to deficiency of what process.

Earning:   Approval pending.