Jawaharlal Nehru Technological University Kakinada 2010-1st Sem B.Pharm II BPharmacyRegular , ember- Pharmaceutical Organic Chemistry- II - Question Paper

B. Pharm (JNTU-K)
II B. Pharmacy 1st Semester Regular Examination, November- 2010
Pharmaceutical Organic Chemistry- II

Time: three Hours Max. Marks: 80

Note: 1) ans any 5 ques. from the subsequent.
2) All ques. carry equal marks.

Ques one a) Write the nomenclature, numbering and 2 characteristic reactions of quinolines and acridines.
Ques one b) discuss the acidity/basicity and their reactivities towards substitution reactions of thiophene and Pyrrole.

Ques two a) Write about the different sequence rules in absolute configuration and add detailed note on relative Configuration with examples.
Ques two b) elaborate elements of symmetry and discuss them with examples.

Ques three a) describe the terms:
i) Chirality
ii) Enantiomers
iii) Meso compounds
iv) E-Z configuration
Ques three b) Write about oxidation-reduction reactions and osazone formation of monosaccharides.

Ques four a) Classify carbohydrates and elucidate the ring structure of glucose.
Ques four b) Write the structural components and pharmaceutical importance of starch and cellulose.

Ques five a) Classify amino acids? define the different methods for the determination of C-terminal and N-terminal residues in proteins.
Ques five b) Write about:
i) Iso electric point
ii) Zwitter ion
iii) Epimerization
iv) Mutarotation

Ques 6) Write the mechanism and applications of:
i) Hoffmann rearrangement
Ques six ii) Beckmannrearrangement
Ques six iii) Mannich reaction
Ques six iv) Phillips condensation reaction

Ques seven a) Write the structure and pharmaceutical importance of uric acid, caffeine, theophylline and theobromine.
Ques seven b) Write a note on characterization of lipids.

Ques 8) Write short notes on:
a) RNA and DNA structures
Ques eight b) Primary, secondary and tertiary structures of proteins

Earning:   Approval pending.