Ganpat University 2009 M.Pharm Advanced medicinal Chemistry - Question Paper
GANPAT UNIVERSITY M.PHARM SEMESTER EXAMINATION-2009 Sub: Advanced Medicinal Chemistry-II Time: 3 Hours Max. Marks: 80
Instructions:
a. Attempt any three questions from each section including Q: 1 and Q: 4 which are compulsory.
b. Answer and tie both sections separately.
c. Figures to the right indicate marks.
SECTION: I
Q: 1
a. Discuss structure activity relationship, mode of action and chemistry
of Phenothiazine tranquillizers. 10
b. Classify antidepressants and give chemistry and mechanism of action
of tricyclic antidepressants. 10
Q: 2
a. Classify antimalarials and discuss chemistry and mode of actions of drugs used in combination for treatment of malaria. 10
b. Classify drugs used for the diseases produced by mycobacterium and write on therapy used in treatment of tuberculosis. 10
Q; 3
a. What is importance of cell cycle for development of new drug for cancer? Discuss chemistry and mechanism of actions of antimetabolites. 10
b. What are antiviral agents? Write on reverse transcriptor inhibitors. 10
SECTION: II
Q: 4
a. Classify anti-hypertensives and discuss chemistry and mechanism of action of angiotensin II antagonists. 10
b. What are anti-arrhythmic drugs? How they act? Give synthesis of Procanamide and Dispyramide. 10
Q; 5
a. Write on development of fluoroquinolone antibacterials with chemistry, mode of action and SAR. 10
b. Discuss chemistry of beta lactum antibiotics. 10
Q: 6 write short note (any four) 20
a. Radioprotectives
b. Therapies used against ageing
c. Antifilarial agents
d. IIMG-COA reductase inhibitors
e. Synthesis of chloroquine
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| Earning: Approval pending. |
