All India Institute of Medical Sciences 2005 M.D /MS Entrance - Question Paper

a) Stomach
b) Ovary
c) Oral cavity
d) Lung

39. Features, which are evaluated for histological grading of breast carcinoma include all of the subsequent except:
a) Tumour necrosis
b) Mitotic count
c) Tubule formation
d) Nuclear pleomorphism

40. Internucleosomal cleavage of DNA is characteristic of:
a) Reversible cell injury
b) Irreversible cell injury
c) Necrosis
d) Apoptosis

41. Which of the subsequent is not a common site for metastatic calcification?
a)Gastric mucosa
b) Kidney
c) Parathyroid
d) Lung

42. On electron microscopy, amyloid characteristically exhibits:
a) B-pleated sheat
b) Hyaline globules
c) 7.5-10nm fibrils
d) 20-25 nm fibrils

43. Which of the subsequent is not compaitible with a diagnosis of juvenile myelemonocytic leukemia?
a) Peripharal blood monocytosis, more than 1x109/L
b) Increased of bcr/abl fusion gene
c) Presence of bcr/abl fusion gene.
d) GM-CSF hypersensitivity of myeloid progenitors in vitro.

44. A 48 year old woman was admitted with a history of weakness for 2 months. On examination, cervical lympth nodes were obtained enlarged and spleen was palpable two cm beneath the costal margin. Her hemoglobin was 10.5g/dl, platelet count 237 x 109/L, which included 80% mature lymphoid cells with coarse clumped chromatin. Bone marrow revealed a nodula lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20 and CD23 and were negative for CD79B and FMC-7.
What is the most likely diagnosis?
a) T-cell rich B-cell lymphoma with leukemic spill over in blood.
b) Chronic lymphocytic leukemia
c) Mantle cell lymphoma
d) A definite diagnosis cannot be made in this patient without lymph node biopsy.

45. All of the subsequent are examples of a round cell tumor, except:
a) Neuroblastoma
b) Ewing's sarcoma
c) Non Hodgkin,s Lymphoma
d) Osteosarcoma

46. Which of the subsequent surface glycoproteins is most often expressed in human hematopoietic stem cell?
a) CD22
b) CD40
c) CD15 `
d) CD34
47. The tumor suppressor gene p53 induces cell cycle arrest at:
a) G2-M phase
b) S-G2 phase

Earning:   Approval pending.