All India Institute of Medical Sciences 2005 M.D /MS Entrance - Question Paper

b) Fanconi Syndrome
c) Huntington's disease
d) Hereditary non polyposis colon cancer
109. The most potent stimulator of naïve T cells is:
a) B Cell
b) Mature dendritic cells
c) Epithelial cells
d) Macrophages
110. Subsitution of which 1 of the subsequent amino acids in place of alanine would increase the absorbance of protein at 280 nm?
a) Leucine
b) Arginine
c) Tryptophan
d) Protein
111. Which of the subsequent situation will lead to increased viscosity of blood?
a) Fasting state
b) Hypoglycemia
c) Multiple myeloma
d) Amyloidogenesis
112. If cellular proteins do not fold into a specific conformation their functions are affected. Certain disorders arise, if specific proteins are misfolded. Which of the subsequent disorders arises due to conformational isomerization?
a) Familial fatal insomnia
b) Hepatitis delta
c) Pernicious anemia
d) Lesch-Nyhan Syndrome
113. Side effects of a drug arise due to the interactions of the drug of molecules other than the target. These effects of a drugs can be minimized by its high:
a) Specificity
b) Affinity
c) Solubility
d) Hydrophobicity
114. Secretory proteins are synthesized in:
a) Cytoplasm
b) Endoplasmic Reticulum
c) 1st in cytoplasm and then in Endoplasmic
d) 1st in Endoplasmic Reticulum and then in cytoplasm
115. Tetracycline inhibits protein synthesis by:
a) Inhibiting initiation and causing misreading of mRNA
b) Binding to 30 S subunit and inhibits binding of aminoacyl tRNA
c) Inhibiting peptidyl transferease activity
d) Inhibiting translocation
116. At physiological pH, the carboxy-terminal of a peptide is:
a) Positively charged
b) Negatively charged
c) Neutral
d) Infinitely charged
117. Which of the subsequent drugs has covalent interaction with its target?
a) Aspirin
b) Penicillin
c) Nitric oxide
d) Bosentan
118. Which of the subsequent property of drug will enable it to be used in low concentrations?
a) High affinity ans
b) High specificity
c) Low specificity
d) High stability
119. Several studies have shown that 85% of cases of lung Cancer are due to cigarette smoking. It is a measure of:

Earning:   Approval pending.