Gujarat Technological University 2010 M.Pharm Pharmacometrics and methods of biological evaluation of drugs. - Question Paper
GUJARAT TECHNOLOGICAL UNIVERSITY
M. Pharmacy Sem-II Examination July 2010
Seat No. Enrolment No.
Subject Name: Pharmacometrics and methods of biological evaluation of drugs. Date: 05 /07 /2010 Time: 11.00 am - 02.00 pm
Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
(a) Define bioassay and discuss briefly the different methods for 06 bioassay of Insulin.
(b) Ennumerate models for evaluation of Sympathomimetics and discuss 05 any three in breif
(c) Write a short note on Pyrogen test 05
Q.2
(a)
(b) (c)
(a)
(b)
(c)
(a)
(b) (c)
(a)
(b) (c)
(a)
(b) (c)
05
05
06 05
05
06
05
05
06 05
05
06 05 05
Q.3
Q.4
Q.5
Q. 6
Q.7
(a)
(b)
(c)
06
05
05
Discuss various methods of inducing hypertension in rats and explain indirect method of recording blood pressure in rats.
Discuss the principle and use of the following-
i) Cooks pole climbing apparatus
ii) Plethysmograph
Write a short note on evaluation of anti ulcer drugs.
Enumerate various models for evaluation of thyroid analogues and discuss any two of them in detail.
Explain methods for inducing cataract in animals.
Write a short note on Lagendorff s preparation for evaluation of cardiovascular drugs.
Discuss chemical and electrical methods of inducing arrhythmias. Explain how antiepileptic agents are evaluated biologically.
Write briefly about models for inflammatory bowel disease.
Discuss the principle involved in evaluation of anti asthmatic agents using different models.
Discuss the principle and use of the following-i) Plus maze apparatus ii)Analgesiometer Describe briefly-
i) Diet induced hyperlipidaemia
ii) Coronary artery ligation method for coronary vasodilators.
Explain microbiological assay of vitamins
Discuss methods for evaluation of anti muscarinic activity of
Parasympatholytic agents.
Write a short note on evaluation of antianxiety agents.
Define LD50 and ED50 and explain their determination. Explain how 06 acute toxicity test is carried out in animals.
Discuss evaluation of anti psychotic agents using behavioural models.
Write a short note on diabetic animal models.
|
Attachment: |
| Earning: Approval pending. |
