Gujarat Technological University 2010 M.Pharm Cellular & Molecular Pharmacology - Question Paper

Q.1 (a) discuss different routes by which small molecules cross cell 06
membranes. Write a note on carrier-mediated transport mechanism.
(b) Classify various kinds of drug antagonism. Write a note 05
on antagonism by receptor block.
(c) Write a note on radio ligand binding studies. 05
Q.2 (a) Classify and what are various kinds of receptors with 06
suitable examples.
(b) explain signal transduction mechanisms by GPCR. 05
(c) elaborate cytokines? explain their actions and role in 05
inflammation.
Q.3 (a) explain muscarinic receptors and their subtypes with 06
reference to their location, cellular and functional response.
(b) explain signaling pathways that outcome in apoptosis. 05
(c) explain the impact of receptor mal function in 05
pharmacotherapeutics
Q.4 (a) Write a note on pharmacology of potassium channels. 06
(b) Write a note on GABA receptors with suitable agonists and 05
antagonists.
(c) Write a note on gene therapy. 05
Q.5 (a) provide an account of 5-HT receptors in the CNS. 06
(b) Write pharmacology of purines. 05
(c) explain the role of NO in different physiological functions. 05
Q.6 (a) Write a note on NMDA receptors suitable agonists and 06
antagonists.
(b) Write pharmacology of calcium channels and their 05
modulators.
(c) Dwell upon dopaminergic pathways and their functions. 05
Q.7 (a) discuss impact of oxidative stress as 1 of the mechanism 06
of neuronal death.
(b) Write pharmacological classification of adrenoceptors and 05
their effects.
(c) elaborate leucotrines? discuss their role in inflammation. 05

Earning:   Approval pending.