Gujarat Technological University 2008-1st Sem B.Pharm 08/uary 09 - Question Paper

Seat No:________ Enrolment No:________
(P-5)
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm. Sem-1 exam December 08/January 09

Pharmaceutics-I(210005)

DATE:29-12-2008, Monday TIME: 11.00 am to 2.00 pm MAX.MARKS:80

Instruction:
Attempt any 5 ques..
Make suitable assumption wherever necessary.
Figure to the right indicate full marks.
Draw tagged diagrams wherever needed.
Q.1 (a) Define: Filtration 01
(b) discuss factors affecting filtration. 05
(c) A rotary filter rotates at the speed of two rpm. The fraction of total filtering area immersed 05
in the slurry is 0.20. Under the provided operating condition, it delivers 1.5 cubic of the
filtrate per minute per square feet of submerged are. If six feet cube of the filtrate is
delivered per revolution by this rotary filter, what is the total area of the filter cloth on
the drum?
(d) discuss brief centrifugal effect. Enumerate application of centrifugation in pharmacy 05

Q.2 (a) describe centrifugation. 01
(b) discuss the construction, working, advantages, and disadvantages of perforated basket
centrifuge. 05
(c) Write a note on cartridge filters. 05
(d) discuss the construction and working of filter-press. 05

Q.3 (a) Define: Evaporation. 01
(b) Draw a tagged diagram of falling film evaporator. define it in brief. 05
(c) discuss factors affecting rate of evaporation. 05
(d) Explain: Volatility and Relative Volatility. Enumerate ideal requirements of a condenser. 05

Q.4 (a) Define: Distillation. 01
(b) Write a brief note on distillation column (fractionating column). 05
(c) A liquid mixture of ethyl alcohol and water is in equilibrium with a vapour containing 05
ethyl alcohol and water at a total pressure of 160mmHg. A sample of vapour shows
that it contains 3.3 moles of ethyl alcohol for every 1.7 moles of water . If the liquid has
a mole fraction 0.52 of ethyl alcohol, what is the relative volatility of the mixture?
(d) discuss i) Duhring’s Rule ii) Roult’s legal regulations. 05

Q.5 (a) Define: Equilibrium Moisture Content (EMC) 01
(b) discuss factors affecting selection of dryers used in manufacturing of pharmaceutical
products. 05
(c) Draw the drying rate curve and discuss the various stages in drying of solids. 05
(d) discuss the term “refrigerant”. Enumerate ideal properties of refrigerant. 05

Q.6 (a) Define: Percentage relative humidity (%RH) 01
(b) discuss the advantages of protecting pharmaceutical products from atmospheric humidity
during their manufacturing and storage. Suggest a few methods of humidity control. 05
(c) What is Lyophilisation? discuss in brief application of lyophilisation. 05
(d) discuss construction and working of “Fluidized Bed Dryer” 05
Q.7 (a) Suggest 1 application of the following: 04
i) Membrane filter ii) Leaf Filter iii) Tray Dryer iv) Spray Dryer
(b) discuss the term : “ Adiabatic Condition”. 02
(c) State whether the subsequent sentence are actual or false. 10
Justify your ans.
Separation in centrifugation is based on the difference in densities.
Azeotropic mixture of ethanol and water cannot be separated by imple distillation process.
Thermolabile substances can be dried using microwave oven.
Silica Gel can be used as refrigerant.
Rate of filtration increases with increase in temperature of slurry.

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Earning:   Approval pending.