Gujarat Technological University 2009 B.Pharm Pharmaceutical Chemistry -III - Question Paper
B.Pharm Sem-III
Pharmaceutical Chemistry III (c) Explain dehydration of alcohol with example for supporting its 05
orientation.
Q.5 (a) Give general methods for the preparation of Alkyne and Alkene 06
(b) How Hyperconjugation and resonance differ from each other? 05 Discuss with example.
(c) Give structural formula for the following 051. 2-methoxypentane
2. N-butyl methyl ether
3. 2-methyl-2-butene
4. Vinyl bromide
5. 1 -methoxy-2-propanol
Q. 6 (a) Define the following 06
1. Markonikovs rule
2. Ozonolysis
3. Peroxide effect
(b) Give general methods for the preparation of Alkyl halide 05 (c) Give IUPAC name of the following 051) CH3 2) CH2CH2
I I I
CH3cch3 oh oh
I
F
3) CH3 4) OCH2-CH3
I 'I
ch3-ch2-ch-ch,-ch3 ch3chch,ch3
I
ch3
5) CH3CH=CHCH3 Q.7 (a) Method of preparation of cycloalkanes. 06
(b) Write a note on the following 05
1. Aldol condensation
2. Clasien condensation
(c) An organic substance on analysis was found to contain 10.06 per 05 cent carbon. 0.84 percent hydrogen and 89.10 per cent chlorine.
Calculate its empirical formula
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Seat No.: p- 1 &4 Enrolment No. nTZ I S,o2 oooT
GUJARAT TECHNOLOGICAL UNIVERSITY B. Pharmacy Seni-III Examination December 2009 Subject code: 230003 Subject Name: Pharmaceutical Chemistry-III Date: 19/12/2009 Time: 12.00-3.00 pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.l (a) Write a note on: halogenations of Alkanes 06
(b) Define hybridization? Explain Sp2 hybridization with example. 05
(c) Explain Following Terms 05
1. Heterolysis
2. Homolysis
3. Dipole-Dipole interaction
4. Antibonding orbital
5. Steric effect
Q.2 (a) Distinguish the Following 06
1. 1-Hexene and n-Hexane
2. Propene and propane
3. Acetylene and Ethylene
(b) Describe preparation and synthetic utility of Cirignard reagent 05
(c) Write a note on Williamsons synthesis of ether. 05
Q.3 (a) Discuss mechanism of SN1 and SN2 reactions of alkyl halides 06
(b) Explian the Following 05
1. Carbenes as reaction intermediates
2. Carbocations with mechanism
(c) Complete the following reactions 05
Pt-Al203
1. n- Haptane ----------------->
600C/10 atm ?
2. Ethene + Cl? --------------->
?
3. n-Butane ----------------> Isobutane.
Q.4 (a) How will you distinguish between primary, secondary and teritary 06 alchol.
(b) Write a note on the following 05
1. Sigmatropic reactions
2. Neighbouring group effects
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