Gujarat Technological University 2009 B.Pharm Physical Pharmaceutics-II - Question Paper
Physical Pharmaceutics-II
B.Pharm-Semester - III
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009 Subject code: 230001 Subject Name: Physical Pharmaceutics II
Date:15 / 12 / 2009 Time: 12.00- 3.00pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.l (a) Enlist different methods to determine Molecular weight of non electrolytes 06 solutions. Explain any one method in detail.
(b) State Raoults law. Explain in details about positive and negative deviations 05 from Raoults law.
(c) Define Molality and Normality. What are colligative properties? State the 05 Henry's law.
Q.2 (a) Explain the theory of strong electrolytes. 06
(b) Define electric current. Explain electrolysis in an electrolytic cell. 05
(c) Describe the Arrheniuss theory of electrolytic dissociation. 05
Q.3 (a) Derive the equation for the second order of reaction (a = b and a *b). 06
(b) Enlist different factors affect the rate of reaction. Discuss in details the 05 effect of temperature on it.
(c) Write a short note on Accelerated stability study. 05
Q.4 (a) Derive the equation for protein binding to draw Scatchcirdplot with its 06
limitations.
(b) Write a short note on chelates and polymer complexes. 05
(c) What are different methods to determine the order of a reaction? Discuss the 05 half life method in detail.
Q.5 (a) Elaborate the different applications of polymers in pharmaceutical field. 06
(b) How to characterize polymers? Explain with different methods. 05
(c) Enlist any two synthetic polymers. Discuss any two general properties of 05 polymer solutions.
Q. 6 (a) Explain in details "Noyes-Whitneyequation for dissolution. 06
(b) What is flux? Explain Ficks first law of diffusion. 05
(c) What is dissolution? Explain dissolution apparatus as per USP method I. 05
Q.7 (a) Comment on 06
i) Expiry date and shelf life is same.
ii) Dissolution rate is increased with increase the rate of stirring.
iii) Diffusion across the membrane depends on concentration of drug.
<b) CH3COOC2H5 + NaOH -> CH3COONa + C2H5OH - 05
The initial concentrations of both the substances in the mixture= 0.02 M.
The change in concentration of alkali during 20 min. = 0.000283 mole/liter. Calculate
i) Rate constant and ii) twof the reaction.
(c) Write a short note on Diffusion Cells. 05
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