Gujarat Technological University 2009-2nd Sem B.Pharm acy (Pharmaceutics-II) - Question Paper
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-II examination June 2009
Subject code: 220002 Subject Name: Pharmaceutics-II
Date: 09/06/2009 Time: 11:30am-2:30pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Comment: Fluid energy mill is suitable for grinding thermolabile materials.
(b) Describe colloid mill with working diagram.
(c) Describe ball mill with working principle.
(d) Describe theories for energy requirement in size reduction.
Q.2 (a) Comment: When vegetable drugs are ground and sifted, none must be rejected.
(b) Explain angle of repose, Carrs Index and Hausner ratio with significance.
(c) Describe pharmacopoeial standards for sieves.
(d) Explain elutriation. Describe multistage elutriation process.
Q.3 (a) Comment: Turbine mixers are suitable for emulsification.
(b) Describe the factors affecting powder mixing.
(c) Enlist mixers for semisolids. Describe planetary mixer.
(d) Classify liquid mixers. Describe propeller mixers.
Q.4 (a) Explain Co-crystals with examples
(b) Explain nucleation. Describe factors affecting crystal growth.
(c) Describe Miers theory for supersaturation with limitations.
(d) Describe Swenson- Walker crystallizer with diagram.
Q.5 (a) Explain Extraction and Manstrum.
(b) Discuss methods of solvent recovery in extraction process.
(c) Describe Soxhlet apparatus for extraction.
(d) Calculate the % crystal yield of glauber salt (Na2SO4-10 H2O) if a pure32% solution is cooled to 20 oC without any evaporative loss. (Solubility of glauber salt is 19.4 gm/ 100 gm water).
Q. 6 (a) Differentiate: Compaction and Consolidation.
(b) Discuss Heckel and Kawakitas equation w.r.t. compression.
(c) Describe different phases of compression for tableting.
(d) Describe Direct Compression technology for tablet manufacturing. Q.7 (a) Explain automated process control. Discuss key elements for the
same.
(b) Describe automation for temperature control.
(c) Write brief note on fire extinguishers.
(d) Describe methods for waste water treatment in pharmaceutical industry
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