Gujarat Technological University 2009 B.Pharm Pathophysiology - Question Paper
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009
Subject code: 230005 Subject Name: Pathophysiology
Date: 23 / 12 / 2009 Time: 12.00 - 3.00 pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Explain the cellular and molecular mechanism of reversible and 06 irreversible cell injury due to hypoxia/ischaemia.
Define apoptosis. Describe causes, molecular mechanism and 06 importance of apoptosis.
Define and classify amyloidosis. Write a note on localised amyloidosis 04
Enumerate cell and plasma derived inflammatory mediators. Describe 06 the role of different systems in generation of plasma derived mediators Enlist the various inflammatory cells and discuss their role in 06 inflammation.
Discuss in detail about wound healing process.
(a)
(b)
(c)
(a)
(b) (c)
(a)
(b) (c)
(a)
(b) (c)
(a)
(b) (c)
Q.2
04
06
06
04
06
06
04
Q.3
Q.4
Q.5
Discuss the pathogenesis, clinical manifestations and diagnosis of AIDS.
Discuss the etiology and pathogenesis of B-cell mediated hypersensitivity reactions with suitable examples.
Explain the role of cyclin/cdks in cell proliferation.
Define autoimmunity and classify autoimmune disease. Write a note on SLE.
Discuss the cells of immune system and their function.
Define and classify cellular adaptations. Write the causes of atrophy and hyperplasia.
Classify environmental and nutritional disease. Write a note on 06 nutritional disease.
Discuss the role of cytokines and free radicals in different phase of 06 inflammation.
Describe the principles of transplantation and mechanism of allograft 04 rejection.
Q. 6
16
Write Short Notes of the following: (Any Four)
a) Biological effects of radiation
b) Vascular events in acute inflammation
c) Extracellular matrix
d) HLA system and its importance
e) Carbon monoxide poisoning
Differentiate the following:
a) Apoptosis and Necrosis
b) Dystrophic and Metastatic calcification
c) Chemotaxis and Phagocytosis
d) Acute and Chronic inflammation
Q.7
16
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Attachment: |
| Earning: Approval pending. |
