Gujarat Technological University 2009 B.Pharm Pharmaceutical Analysis – I - Question Paper
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009
Subject code: 230004 Subject Name: Pharmaceutical Analysis - I
Date: 21 / 12 / 2009 Time: 12.00 - 3.00 pm
Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Enumerate areas of application of acid-base buffers. Derive 06 Henderson-Hasselbach equation for finding pH of buffer solution.
(b) Calculate pH of solution resulting by mixing 50 ml 0.2N NaOH and 05 50 ml 0.4 N CH3COOH, pKa of Acetic acid is 4.76.
(c) I. Why is phenolphthalein colorless below pH 8.3 and above 05
pH 13?
II. Acetic acid is a leveling solvent as well as differentiating solvent.
What is hydrolysis? Derive equation for finding pH of aqueous solution of salt of weak acid and strong base.
Calculate pH and degree of hydrolysis in 0.1 M Ammonium chloride solution. Kb is 1.8 X 10-5.
Write note on composition and standardization of Karl Fischer Reagent? Give reaction involved in the Karl Fischer Reagent.
Write a note on estimation of Nitrogen in organic compounds by Kjeldhal method.
25ml of 0.1M Acetic acid is titrated with 0.1N NaOH. Calculate the pH of the solution when volume of NaOH is added. (Ka is 1.82 x 105)
I. 0.0 ML
II. 5 ML
III. 25 ML
IV. 30 ML
I. Write a short note on ionic product of water.
II. Explain the term: Precision, Accuracy and LOD.
Q.2
(a)
(b) (c)
(a)
(b)
06
05
05
Q.3
06
05
(c)
05
Explain theroy of multiple solvent extrations.
A 20 aliquot of 0.4% w/v aqueous solution of acetanilide was extracted with (I) 30 ml ether (II) three times with 40 ml portion of ether. The ether/water partition co-efficient for acetanilide is 3.0. Calculate total amount of drug extracted in each case?
I. How the pH will affect the extractability of drugs.
II. What is difference between QA and QC?
Q.4
(a)
(b)
06
05
(c)
05
Q.5 (a) Write a note on Diazotization nitrite titration. 06
(b) Write a note on Iodometric titration. 05
(c) I. Equivalent weight of KMnO4 changes with the media. 05
II. Define the solvent used in non aqueous titration.
Q. 6 (a) Types of complexometric titrations. Masking and damasking of 06 complexometric titration.
(b) Explain importance of von-Weimar ratio, co-precipitation and post- 05 precipitation in gravimetric method of estimation.
(c) pM Indicator 05
Q.7 (a) Explain the term solubility product constant. Discuss applications of 06 solubility product principle in analysis.
(b) Write a note on the determination of halogen by Volhards method. 05
(c) Classify sources of analytical errors. How can they be minimized. 05
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