Gujarat Technological University 2009 B.Pharm Pharmaceutical Chemistry-III - Question Paper
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009 Subject code: 230003 Subject Name: Pharmaceutical Chemistry-III Date: 19 / 12 /2009 Time: 12.00 - 3.00 pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Write a note on: halogenations of Alkanes 06
2
(b) Define hybridization? Explain Sp hybridization with example. 05
(c) Explain Following Terms 05
1. Heterolysis
2. Homolysis
3. Dipole-Dipole interaction
4. Antibonding orbital
5. Steric effect
Q.2 (a) Distinguish the Following
06
05
05
1. 1 -Hexene and n-Hexane
2. Propene and propane
3. Acetylene and Ethylene
(b) Describe preparation and synthetic utility of Grignard reagent
(c) Write a note on Williamsons synthesis of ether.
Q.3 (a) Discuss mechanism of SN1 and SN2 reactions of alkyl halides
06
05
05
(b) Explian the Following
1. Carbenes as reaction intermediates
2. Carbocations with mechanism
(c) Complete the following reactions
Pt-Al2O3
1. n- Haptane .................>
600C/10 atm ?
2. Ethene + Cl2 ...............>
?
3. n-Butane ................> Isobutane.
Q.4 (a) How will you distinguish between primary, secondary and teritary 06 alchol.
1. Sigmatropic reactions
2. Neighbouring group effects
orientation.
Q.5 (a) Give general methods for the preparation of Alkyne and Alkene 06
(b) How Hyperconjugation and resonance differ from each other? 05 Discuss with example.
1. 2-methoxypentane
2. N-butyl methyl ether
3. 2-methyl-2-butene
4. Vinyl bromide
5. 1 -methoxy-2-propanol
Q. 6 (a) Define the following 06
1. Markonikov s rule
2. Ozonolysis
3. Peroxide effect
1) CH3 2) CH2---CH2
I I I
CH3---C---CH3 OH OH
I
F
CH3--CH2--CH--CH2--CH3 CH3---CH---CH2---CH3
5) CH3---CH=CH---CH3 Q.7 (a) Method of preparation of cycloalkanes. 06
(b) Write a note on the following 05
1. Aldol condensation
2. Clasien condensation
(c) An organic substance on analysis was found to contain 10.06 per 05 cent carbon, 0.84 percent hydrogen and 89.10 per cent chlorine.
Calculate its empirical formula
2
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| Earning: Approval pending. |
