Gujarat Technological University 2008 B.Pharm Semester-II - Question Paper
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-II examination June 2009
Seat No. Enrolment No.
Subject code: 220004 Subject Name: APHE-II
Date: 11/06/2009 Time: 11:30am-2:30pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Define Blood pressure. Discuss various methods for measurement of blood pressure and various factors affecting blood pressure
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(b) Define Nervous system. Write the difference between Parasympathetic nervous system and Sympathetic nervous system.
(c) Write a note on medulla oblongata.
Q.2 (a) Draw a neat and labeled diagram of Eye. Explain the Physiology of Vision.
(b) Define Cardiac cycle. Describe each event in detail. How it correlates with ECG ?
(c) Draw and Explain Male reproductive system.
Q.3 (a) Draw a neat labeled diagram of Heart. Describe Anatomy and Physiology of Heart.
(b) Expain the Physiology of Urine formation.
(c) Draw a neat and labeled diagram of functional unit of kidney Q.4 Write Short Notes on following
(a) Cranial nerve
(b) Electroencephalogram
(c) Menstrual cycle
(d) Internal respiration
Q.5 Explain the following disease with its clinical features
(a) Goitre
(b) Glaucoma
(c) Asthma
(d) Renal Calculi
Q. 6 (a) Enumerate hormones of Adrenal gland and explain their physiological role in the body
(b) Draw a neat and labeled diagram of Brain. Write the function of Hypothalamus.
(c) Structure and function of skin Q.7 Explain the following terms
(a) Neurons (b)
Action Potential
Neurotransmitter
CSF
Endocrine gland
(c) Pheromones (d)
(e) Hormones (f)
(g) Photoreceptors (h)
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GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-II examination June 2009
Subject Name: Applied Mathematics (Biostatistics)
Time : 11:30am-2:30pm Total Marks: 80
Subject code: (220001) Date : 08/06/09
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q-1
A
B
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C
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What is correlation? Distinguish between positive, negative and zero correlation. | ||||||||||||||||||||||
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i) Find the correlation coefficient between age and blood pressure. ii) Determine least square regression equation of blood pressure on age Estimate the blood pressure of women whose age is 45 years. A Beers law plot is constructed by plotting ultraviolet absorbance vs. concentration, with following result:_ |
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Concentration ( x) |
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2 |
3 |
5 |
10 |
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Absorbance ( y) |
0.10 |
0.36 |
0.57 |
1.09 |
2.05 |
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XY |
0.10 |
0.72 |
1.71 |
5.14 |
20.50 |
i) Calculate slop and intercept
ii) An unknown has an absorbance of 1.65. What is the concentration?
D Obtain the rank correlation coefficient between Fasting blood glucose level and systolic 03
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blood pressure in 10 diabetic patients. | |||||||||||||||||||||||||||||||||
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Q-2 A What is analysis of variance? 01
C Eight laboratories were requested to participate in experiment whose objective was to 07 compare the dissolution rates of two generic products and standard product. The purpose of the experiment was to determine.
i) If the product had different rates of dissolution.
ii) To estimate the laboratory variability and test for significance difference among laboratories. Carry out two-way ANOVA for the given data and give your conclusion
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( From the F distribution table- F 2,14= 3.74,F7,24=2.43 and F14 ,24= 2.13 at 5%level of significance ) |
D The hemoglobin level of three group of children fed on three different diets are given in 05
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( From F distribution table F2,30 = 3.32 at 5%level of significance | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Q-3 A Explain the following terms related to testing of hypothesis. 04
i) Null hypothesis
ii) Alternate hypothesis
iii) Level of significance
iv) Standard error.
B A clinical research center of Zydus Cadila pharmaceutical conducted a pharmacokinetic 06 study in 12 human volunteer. The maximum therapeutic concentration of drug in plasma(C max) was studied after administration of new formulation and established formulation.
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Test whether there is statistical significance of difference between the two formulations. (t n,0.05=2.20 at 5% significance level) C The following data shows the blood pressure reduction (in mmHg) caused in 10 animal by a new antihypertensive compound. Test the hypothesis that blood pressure reduction for population in 15 mm Hg. (t9,0.05=2.262 at 5% significance level) |
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Blood pressure |
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18 |
14 |
8 |
90 |
12 |
17 |
21 |
16 |
18 |
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reduction (mm Hg.) |
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B
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Q-5
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B
C
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Q-4 A Enumerate the experimental designs in clinical trials? Discuss in detail about any one experimental design.
Explain following terms with reference to experimental designs in clinical trials. i) Wash out period ii) Carry over effect
iii) Replicate design iv) Crossover Design
What is type I and type II errors.
Discuss in brief chi square test or goodness of fit.
Two granulation were prepared by different procedure Seven different random samples of powdered mix of equal weight ( equal to weight Of Final Dosage from) were collected from each batch and assayed for active pharmaceutical ingredient. The test is to be performed at the 5% level. (From F distribution table F 6,0.05=5.8)
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Granulation A |
20.6 |
20.9 |
20.6 |
20.7 |
19.8 |
20.4 |
21.0 |
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Granulation B |
20.2 |
21.5 |
18.9 |
19.0 |
21.8 |
20.4 |
21.0 |
D A certain drug is claimed to be effective in curing colds. In experiment on 500 person 04 with cold, half of them were given the drug and half of them were given sugar pill. The
patients reaction to the treatment is recorded in following table. On the basis of these data conclude that there is significance difference in the effect of drug and sugar pill. The test is to be performed at the 5% level
(Critical value of Chi square x 2 = 5.99 at 2 d.f.)_
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Treatment |
Consequence | |||
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Helped |
Reaction |
No effect |
Total | |
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Drug |
150 |
30 |
70 |
250 |
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Sugar pill |
130 |
40 |
80 |
250 |
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Total |
230 |
70 |
150 |
500 |
E Enumerated the various methods of sampling and discuss in detail about any two 08 methods with suitable examples.
What are the advantages of and characteristics of the sample? 03
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Q-7 A B
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Differentiate between the sampling with replacement and without replacement 02
A population consists of five numbers 2,3,6,8.11. consider all possible size of two which can be drawn with replacement from this population. Calculate the standard error of sample mean
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What arte the advantages of nonparametric tests Write note on followings ( any two )
i) Wilcoxon signed rank test ii) Kruskal wallis test iii) Wilcoxon rank sum test.
A Bioavailability study was conducted in which two products were compared ( A and B formulation ) . The peak blood concentrations were as follows; Use Wilcoxon signed rank test to determine if there is a difference among formulation. (Critical value for T at P= 0.05 for 12 pairs from table = 11)
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thoroughly investigated. One characteristic measures was diastolic blood pressure (mmHg).Is there any reason to believe that the 3 groups differ with these characteristics? | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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( Table value of x 2 5.99 at d. |
\=k-1=2 and alpha = 0.05) | |||||
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Group A |
100 |
103 |
89 |
78 |
105 | |
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Group B |
92 |
97 |
88 |
84 |
90 |
95 |
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Group C |
81 |
102 |
86 |
83 |
99 | |
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GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-II examination June 2009
Seat No. Enrolment No.
Subject code: 220003 Subject Name: Pharm Chemistry-II
Date:10/06/2009 Time: 11:30am-2:30pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a)
(b)
(c)
Q.2 (a)
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(b)
(c)
(a)
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Q.3
(b)
(c)
(a)
(b) (c)
(a)
(b) (c)
(a)
(b)
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Q.4
Q.5
Q. 6
(c)
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Comments on the following
1. Dilution of H2SO4 with water is an endothermic reaction
2. Photochemical reaction follows second order kinetics
3. Liquification process depends on temperature and pressure both Derive reaction rate constant, half life and graph of first order reaction kinetics
Define Activation energy of a chemical reaction, how is it determined?
Differentiate between the following
1. Physical absorption Vs Chemisorption
2. Homo catalysis Vs hetero catalysis
3. Photochemical reaction Vs thermochemical reaction Write a note on Giger muller counter
Write applications of the radioactivity Explain any three terms
1. Degree of freedom 3. Colligative properties
2. Azeotropic mixture 4. Parachor
What is adsorption? Explain Langmuir adsorption isotherm Write application of adsorptions
Write briefly about various types of thermodynamic processes Define thermodynamics. Explain first law of thermodynamics Write in detail about enthalpy of the system & molar heat capacities Define quantum yield of a photochemical reactions giving reasons for high and low quantum yield
Write about beer-lamberts law for photochemical reaction Write about Debye-huckle theory
What is phase rule? Discuss water system with reference to phase rule
Define molarity & molality, Calculate the normality of a solution containing 25.2 g of oxalic acid crystals (Molecular weight: 126) dissolved in 500 ml of solution State and explain Henrys law
Q.7 (a) Write about various methods for the estimation of surface tension 06
(b) Write in detail about factors affecting viscosity 05
(c) Write a note on optical rotation 05
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-II examination June 2009
Seat No. Enrolment No.
Subject code: 220003 Subject Name: Pharm Chemistry-II
Date:10/06/2009 Time: 11:30am-2:30pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a)
(b)
(c)
Q.2 (a)
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05
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06
(b)
(c)
(a)
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05
06
Q.3
(b)
(c)
(a)
(b) (c)
(a)
(b) (c)
(a)
(b)
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06 05
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05
05
06
05
Q.4
Q.5
Q. 6
(c)
05
Comments on the following
1. Dilution of H2SO4 with water is an endothermic reaction
2. Photochemical reaction follows second order kinetics
3. Liquification process depends on temperature and pressure both Derive reaction rate constant, half life and graph of first order reaction kinetics
Define Activation energy of a chemical reaction, how is it determined?
Differentiate between the following
1. Physical absorption Vs Chemisorption
2. Homo catalysis Vs hetero catalysis
3. Photochemical reaction Vs thermochemical reaction Write a note on Giger muller counter
Write applications of the radioactivity Explain any three terms
1. Degree of freedom 3. Colligative properties
2. Azeotropic mixture 4. Parachor
What is adsorption? Explain Langmuir adsorption isotherm Write application of adsorptions
Write briefly about various types of thermodynamic processes Define thermodynamics. Explain first law of thermodynamics Write in detail about enthalpy of the system & molar heat capacities Define quantum yield of a photochemical reactions giving reasons for high and low quantum yield
Write about beer-lamberts law for photochemical reaction Write about Debye-huckle theory
What is phase rule? Discuss water system with reference to phase rule
Define molarity & molality, Calculate the normality of a solution containing 25.2 g of oxalic acid crystals (Molecular weight: 126) dissolved in 500 ml of solution State and explain Henrys law
Q.7 (a) Write about various methods for the estimation of surface tension 06
(b) Write in detail about factors affecting viscosity 05
(c) Write a note on optical rotation 05
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-II examination June 2009
Seat No. Enrolment No.
Subject code: 220002 Subject Name: Pharmaceutics-II
Date: 09/06/2009 Time: 11:30am-2:30pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Comment: Fluid energy mill is suitable for grinding thermolabile materials.
(b) Describe colloid mill with working diagram.
(c) Describe ball mill with working principle.
(d) Describe theories for energy requirement in size reduction.
Q.2 (a) Comment: When vegetable drugs are ground and sifted, none must be rejected.
(b) Explain angle of repose, Carrs Index and Hausner ratio with significance.
(c) Describe pharmacopoeial standards for sieves.
(d) Explain elutriation. Describe multistage elutriation process.
Q.3 (a) Comment: Turbine mixers are suitable for emulsification.
(b) Describe the factors affecting powder mixing.
(c) Enlist mixers for semisolids. Describe planetary mixer.
(d) Classify liquid mixers. Describe propeller mixers.
Q.4 (a) Explain Co-crystals with examples
(b) Explain nucleation. Describe factors affecting crystal growth.
(c) Describe Miers theory for supersaturation with limitations.
(d) Describe Swenson- Walker crystallizer with diagram.
Q.5 (a) Explain Extraction and Manstrum.
(b) Discuss methods of solvent recovery in extraction process.
(c) Describe Soxhlet apparatus for extraction.
(d) Calculate the % crystal yield of glauber salt (Na2SO4-10 H2O) if a pure32% solution is cooled to 20 oC without any evaporative loss. (Solubility of glauber salt is 19.4 gm/ 100 gm water).
Q. 6 (a) Differentiate: Compaction and Consolidation.
(b) Discuss Heckel and Kawakitas equation w.r.t. compression.
(c) Describe different phases of compression for tableting.
(d) Describe Direct Compression technology for tablet manufacturing. Q.7 (a) Explain automated process control. Discuss key elements for the
same.
(b) Describe automation for temperature control.
(c) Write brief note on fire extinguishers.
(d) Describe methods for waste water treatment in pharmaceutical industry
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-II examination June 2009
Seat No. Enrolment No.
Subject code: 220006 Subject Name: Physical Pharmacy
Date: 15/06/2009 Time: 11:30am-2:30pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
(a)
(b)
(c)
(a)
(b) (c)
(a)
(b)
(c)
(a)
(b)
(c)
(a)
(b)
(c)
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Q.2
Q.3
Q.4
Q.5
Q. 6
(a)
(b) (c)
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Define Polymorphism. Discuss the significance of Polymorphism in Pharmacy with example.
Discuss the two component systems containing solid and liquid Phases.
Write a note on liquid Crystals.
What is Buffer capacity? How it is calculated?
Write a note on Pharmaceutical Buffer.
Calculate the pH of 0.02 M Ba(OH)2.
Write in detailed note on Non-Newtonian systems.
Classify various viscometers. Describe two viscometer with diagram to find out viscosity of Non-Newtonian fluids.
What a note on : Plastic and Pseudoplastic flow.
Differentiate various types of colloidal dispersion system and give the application of colloids in pharmacy.
Define Suspension. Write a note on factors affecting stability of Suspension.
Discuss the instability of emulsions.
Discuss the method of determining the particle volume in detail. Discuss the porosity and Kelvin equation with their significance in pharmacy.
A sample of calcium carbonate having density 2.8 g/cm , allow to settle under acceleration of gravity (gc = 980 cm/sec) the rate of setting (v) is 14.6 X 10-3 cm/sec, the density (p) of water is 1.00g/cm3 and viscosity (n) is 0.01 poise. Calculate the Stokes Diameter. Explain the Surface and Interfacial tensions.
What is spreading Coefficient? Derive its equation.
Describe the method of calculation of HLB by different techniques.
Q.7 (a) Write a note on solubility of gases in liquid.
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(b) Write a note on law of distribution.
(c) Write a note on physical stability of emulsion.
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Attachment: |
| Earning: Approval pending. |
