Gujarat Technological University 2009 B.Pharm acy SIM-III - Question Paper
B.Pharmacy SIM-III QPaper of Academic Year 2009.10
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009 Subject code: 230001 Subject Name: Physical Pharmaceutics II
Date: 15 / 12 / 2009 Time: 12.00- 3.00pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Enlist different methods to determine Molecular weight of non electrolytes 06 solutions. Explain any one method in detail.
(b) State Raoults law. Explain in details about positive and negative deviations 05 from Raoults law.
(c) Define Molality and Normality. What are colligative properties? State the 05 Henrys law.
Q.2 (a) Explain the theory of strong electrolytes. 06
(c) Describe the Arrheniuss theory of electrolytic dissociation. 05
Q.3 (a) Derive the equation for the second order of reaction (a = b and a b). 06
(b) Enlist different factors affect the rate of reaction. Discuss in details the 05 effect of temperature on it.
(c) Write a short note on Accelerated stability study. 05
Q.4 (a) Derive the equation for protein binding to draw Scatchardplot with its 06 limitations.
(c) What are different methods to determine the order of a reaction? Discuss the 05 half life method in detail.
Q.5 (a) Elaborate the different applications of polymers in pharmaceutical field. 06
(c) Enlist any two synthetic polymers. Discuss any two general properties of 05 polymer solutions.
Q. 6 (a) Explain in details Noyes-Whitney equation for dissolution. 06
(c) What is dissolution? Explain dissolution apparatus as per USP method I. 05
Q.7 (a) Comment on 06
i) Expiry date and shelf life is same.
ii) Dissolution rate is increased with increase the rate of stirring.
iii) Diffusion across the membrane depends on concentration of drug.
The initial concentrations of both the substances in the mixture= 0.02 M.
The change in concentration of alkali during 20 min. = 0.000283 mole/liter. Calculate
i) Rate constant and ii) t1/2 of the reaction.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009 Subject code: 230002 Subject Name: Pharmaceutical Engineering II
Date:17 / 12 /2009 Time: 12.00 - 3.00pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Explain techniques used for improvement of powder flow. 06
Q.1
(a)
(b)
(c)
Define content uniformity. Give significance of content uniformity 05 in pharmacy field.
What is control chart? 05
In the quality control, 1000 tablets were inspected for weight variation and 2.5% were found out of limit range. What are the upper and lower 3o limits for this?
Q.2
Discuss in detail about factors affecting quality of pellet in 06
(a)
(b) (c)
(a)
(b)
Extrusion-Spheronization.
Enlist methods used for measurement of powder flow. Explain BP 05 recommended procedure for density measurement.
Write a note on sampling techniques for content uniformity test. 05
Q.3
Enlist application of SCF. Discuss in detail about pharmaceutical 06 application.
Describe weight uniformity % deviation limit as per IP 2007. 05
Cefadroxil tablets were prepared each containing 500 mg of Cefadroxil. The prepared tablets were evaluated for weight uniformity test. Find out whether tablets full fill the requirement of IP 2007 or not? Data of individual weight (mg) of tablets are as follows.
1. 617 2. 625 3. 624 4. 616 5. 632 6. 615 7. 628
8. 630 9. 626 10. 619 11. 633 12. 606 13. 636 14. 640
15. 625 16. 621 17. 633 18. 626 19. 622 20. 618
Explain direct methods for powder flow measurement. 05
(c)
Q.4 (a)
Describe terms arching and rat holing. 06
Lactose granules was prepared by wet granulation method and evaluated for compressibility and flow property. Data of evaluation parameters of 10 gm granules are as follow.
Bulk volume : 48 cc Tapped volume: 42 cc
Heap height : 3 cm Heap diameter : 11.5 cm
Calculate Hausner ratio, Carrs index and angle of repose of granules and give your comment.
Enlist control charts for attributes and explain c chart. 05
(b)
(c)
Write a note on Rotary cylinder extruder. 05
|
Q.5 |
(a) |
Write a note on particles from gas-saturated solution. |
06 |
|
(b) |
Define critical orifice diameter. Describe flow through an orifice method. |
05 | |
|
(c) |
Discuss content uniformity acceptance criteria as per BP. |
05 | |
|
Q. 6 |
(a) |
Describe various methods used for measurement of angle of repose. |
06 |
|
(b) |
Draw schematic diagram of control chart and describe elements of control chart. |
05 | |
|
(c) |
Explain cryopelletization. |
05 | |
|
Q.7 |
(a) |
Define HME and explain its significance in Pharmaceutical Industry. |
06 |
|
(b) |
Give significance of SCF in particle engineering and explain RESS technology. |
05 | |
|
(c) |
Write a note on interpretation of control charts |
05 |
2
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009 Subject code: 230003 Subject Name: Pharmaceutical Chemistry-III Date: 19 / 12 /2009 Time: 12.00 - 3.00 pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Write a note on: halogenations of Alkanes 06
2
(b) Define hybridization? Explain Sp hybridization with example. 05
(c) Explain Following Terms 05
1. Heterolysis
2. Homolysis
3. Dipole-Dipole interaction
4. Antibonding orbital
5. Steric effect
Q.2 (a) Distinguish the Following
06
05
05
1. 1 -Hexene and n-Hexane
2. Propene and propane
3. Acetylene and Ethylene
(b) Describe preparation and synthetic utility of Grignard reagent
(c) Write a note on Williamsons synthesis of ether.
Q.3 (a) Discuss mechanism of SN1 and SN2 reactions of alkyl halides
06
05
05
(b) Explian the Following
1. Carbenes as reaction intermediates
2. Carbocations with mechanism
(c) Complete the following reactions
Pt-Al2O3
1. n- Haptane .................>
600C/10 atm ?
2. Ethene + Cl2 ...............>
?
3. n-Butane ................> Isobutane.
Q.4 (a) How will you distinguish between primary, secondary and teritary 06 alchol.
1. Sigmatropic reactions
2. Neighbouring group effects
orientation.
Q.5 (a) Give general methods for the preparation of Alkyne and Alkene 06
(b) How Hyperconjugation and resonance differ from each other? 05 Discuss with example.
1. 2-methoxypentane
2. N-butyl methyl ether
3. 2-methyl-2-butene
4. Vinyl bromide
5. 1 -methoxy-2-propanol
Q. 6 (a) Define the following 06
1. Markonikov s rule
2. Ozonolysis
3. Peroxide effect
1) CH3 2) CH2---CH2
I I I
CH3---C---CH3 OH OH
I
F
3) CH3 4) OCH2-CH3
I I
CH3--CH2--CH--CH2--CH3 CH3---CH---CH2---CH3
I
CH3
5) CH3---CH=CH---CH3 Q.7 (a) Method of preparation of cycloalkanes. 06
(b) Write a note on the following 05
1. Aldol condensation
2. Clasien condensation
(c) An organic substance on analysis was found to contain 10.06 per 05 cent carbon, 0.84 percent hydrogen and 89.10 per cent chlorine.
Calculate its empirical formula
2
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009
Subject code: 230004 Subject Name: Pharmaceutical Analysis - I
Date: 21 / 12 / 2009 Time: 12.00 - 3.00 pm
Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Enumerate areas of application of acid-base buffers. Derive 06 Henderson-Hasselbach equation for finding pH of buffer solution.
(b) Calculate pH of solution resulting by mixing 50 ml 0.2N NaOH and 05 50 ml 0.4 N CH3COOH, pKa of Acetic acid is 4.76.
(c) I. Why is phenolphthalein colorless below pH 8.3 and above 05
pH 13?
II. Acetic acid is a leveling solvent as well as differentiating solvent.
What is hydrolysis? Derive equation for finding pH of aqueous solution of salt of weak acid and strong base.
Calculate pH and degree of hydrolysis in 0.1 M Ammonium chloride solution. Kb is 1.8 X 10-5.
Write note on composition and standardization of Karl Fischer Reagent? Give reaction involved in the Karl Fischer Reagent.
Write a note on estimation of Nitrogen in organic compounds by Kjeldhal method.
25ml of 0.1M Acetic acid is titrated with 0.1N NaOH. Calculate the pH of the solution when volume of NaOH is added. (Ka is 1.82 x 105)
I. 0.0 ML
II. 5 ML
III. 25 ML
IV. 30 ML
I. Write a short note on ionic product of water.
II. Explain the term: Precision, Accuracy and LOD.
Q.2
(a)
(b) (c)
(a)
(b)
06
05
05
Q.3
06
05
(c)
05
Explain theroy of multiple solvent extrations.
A 20 aliquot of 0.4% w/v aqueous solution of acetanilide was extracted with (I) 30 ml ether (II) three times with 40 ml portion of ether. The ether/water partition co-efficient for acetanilide is 3.0. Calculate total amount of drug extracted in each case?
I. How the pH will affect the extractability of drugs.
II. What is difference between QA and QC?
(a)
(b)
06
05
(c)
05
Q.5 (a) Write a note on Diazotization nitrite titration. 06
(b) Write a note on Iodometric titration. 05
(c) I. Equivalent weight of KMnO4 changes with the media. 05
II. Define the solvent used in non aqueous titration.
Q. 6 (a) Types of complexometric titrations. Masking and damasking of 06 complexometric titration.
(b) Explain importance of von-Weimar ratio, co-precipitation and post- 05 precipitation in gravimetric method of estimation.
(c) pM Indicator 05
Q.7 (a) Explain the term solubility product constant. Discuss applications of 06 solubility product principle in analysis.
(b) Write a note on the determination of halogen by Volhards method. 05
(c) Classify sources of analytical errors. How can they be minimized. 05
2
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009
Seat No. Enrolment No.
Subject code: 230005 Subject Name: Pathophysiology
Date: 23 / 12 / 2009 Time: 12.00 - 3.00 pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Explain the cellular and molecular mechanism of reversible and 06 irreversible cell injury due to hypoxia/ischaemia.
Define apoptosis. Describe causes, molecular mechanism and 06 importance of apoptosis.
Define and classify amyloidosis. Write a note on localised amyloidosis 04
Enumerate cell and plasma derived inflammatory mediators. Describe 06 the role of different systems in generation of plasma derived mediators Enlist the various inflammatory cells and discuss their role in 06 inflammation.
Discuss in detail about wound healing process.
(a)
(b)
(c)
(a)
(b) (c)
(a)
(b) (c)
(a)
(b) (c)
(a)
(b) (c)
Q.2
04
06
06
04
06
06
04
Q.3
Q.4
Q.5
Discuss the pathogenesis, clinical manifestations and diagnosis of AIDS.
Discuss the etiology and pathogenesis of B-cell mediated hypersensitivity reactions with suitable examples.
Explain the role of cyclin/cdks in cell proliferation.
Define autoimmunity and classify autoimmune disease. Write a note on SLE.
Discuss the cells of immune system and their function.
Define and classify cellular adaptations. Write the causes of atrophy and hyperplasia.
Classify environmental and nutritional disease. Write a note on 06 nutritional disease.
Discuss the role of cytokines and free radicals in different phase of 06 inflammation.
Describe the principles of transplantation and mechanism of allograft 04 rejection.
Q. 6
16
Write Short Notes of the following: (Any Four)
a) Biological effects of radiation
b) Vascular events in acute inflammation
c) Extracellular matrix
d) HLA system and its importance
e) Carbon monoxide poisoning
Differentiate the following:
a) Apoptosis and Necrosis
b) Dystrophic and Metastatic calcification
c) Chemotaxis and Phagocytosis
d) Acute and Chronic inflammation
Q.7
16
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Examination December 2009 Subject code: 230006 Subject Name: Pharmacognosy II
Date: 29 / 12 / 2009 Time: 12.00 - 3.00pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Mention Biological source and Chemical constituents of American & Indian 06 Podophyllum resins.
(b) Comment on quality of various species of Podophyllum and relationship 05 between their chemical constituents & anti- mitotic activity.
drugs.
(c) Write possible difference between Hydrolysable tannins and condensed 05 tannins.
Q.3 (a) Enumerate methods of production of volatile oils illustrating suitable 06 examples. Describe any one of them.
(b) Draw well labeled sketch of Morphology and Microscopy (T.S.) of 05 Coriander fruit. Or Cassia bark
(c) Write a detailed Pharmacognostic note on Volatile oil containing drug used 05 as dental analgesic.
Q.4 (a) Enlist different class of phytoconstituents, elaborate preliminary 06 phytochemical screening of alkaloids and saponins containing drugs.
(b) Explain working principle of Soxhlets apparatus giving well labeled 05 diagram.
Explain the term pharmaceutical aids. Enlist the common sources & Family of crude drugs used as pharmaceutical aids.
Write short notes on Gelatin.
Describe the following chemical tests and state the crude drugs which give this test positive:
(i) Gold beaters skin test (ii) Combined umbelliferone test.
Comment on the following statements :
(i) Raw cotton forms balloons with Cuoxam test.
(ii) Wool is keratin rich fiber.
(iii) Black catechu gives Gambier fluorescence test.
What are surgical fibers? Classify them giving suitable examples. Describe preparation & chemical identification of Silk.
Write in brief note on Absorbent cotton.
Write Biological source, Chemical constituents and uses of following drugs :(Any Two)
Nutmeg or Valerian Turmeric or Cardamom Write in brief on Natural colours
name, their 06
Q.5 (a)
(b)
(c)
05
05
Q. 6 (a)
06
(b)
(c)
05
05
(a)
(b) c)
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Q7
06
05
05
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Attachment: |
| Earning: Approval pending. |
