Gujarat Technological University 2010 B.Pharm Pharmaceutical Analysis- II - Question Paper

B. Pharm
Fourth Semester Examination, June 2010
Subject Code - 240004
Pharmaceutical Analysis- II

Time: three Hrs. Total Marks: 80

Instructions:
1) Attempt any 5 ques..
2) Make suitable assumptions wherever necessary.
3) Figures to the right indicate full marks.

Ques one a) describe and classify chromatography giving suitable examples. (05)
Ques one b) elaborate the retention mechanisms involved in chromatography? discuss any 2 mechanisms in detail. (06)
Ques one c) elaborate the advantages of TLC over paper chromatography? explain the Pharmacopoeial applications of column chromatography. (05)

Ques two a) define the various theories of chromatography. (06)
Ques two b) discuss clearly and briefly every of the subsequent terms: (05)
i) Standard reduction potential.
ii) Equivalent conductance.
iii) Stripping voltametry.
iv) Anodic polarographic wave.
v) Pulse polarography

Ques two c) Draw a neat and well-labeled diagram of reference electrode. If the specific conductance of 0.01N HCl (36.5) is 0.00792mho. What is its equivalent conductance? (05)

Ques three a) define the working of dropping mercury electrode. Write a note on applications of polarography. (06)
Ques three b) explain biamperometric titrations in detail. (05)
Ques three c) define in detail the factors affecting conductance. (05)

Ques four a) describe calorimetry. Enlist the various kinds of calorimetry. (04)
Ques four b) What is the difference ranging from DTA and DSC. State the applications of both the above methods. (06)
Ques four c) Write a note on TGA. (06)

Ques five a) Draw a neat and tagged diagram of polarimeter and explain its applications. (06)
Ques five c) define briefly the working and application of potentiometer. (04)
Ques five c) elaborate the advantages of instrumental analysis over volumetric analysis? define the process of validation in instrumental analysis. (06)

Ques six a) Saturated barium sulphate solution has conductance 3.5µS and that of water is 0.46µS in a cell with cell constant 1.1cm–1. Equi ionic conductance at infinite dilution for 1/2Ba++ = 64 and 1/2SO4– = 80 S.cm2 compute solubility in gram equivalence per litre and %w/v. [Mol.wt of BaSO4 = 234 Da]. (04)
Ques six b) How will you determine the pKa value of acetic acid using pH meter. (06)
Ques six c) Distinguish the subsequent pairs: (06)
i) Stationary phase and mobile phase.
ii) Diffusion current and residual current.
iii) Optically active compound and optically inactive compound.

Ques seven a) compute the water equivalence factor F of Karl Fisher reagent. If a 150mg sample of sodium tartarate dehydrate [230.1] needed 25ml of K.F.R. (04)
Ques seven b) discuss the subsequent statement: (10)
i) Chromatography is a method of separation and not analysis.
ii) Equivalent conductance reduce with increase in concentration.
iii) Nitrogen is passed from solution in polarography.
iv) In the measurement of pH, glass, and calomel electrodes are essential.

Ques seven c) What is the titer of 0.09N HCl [36.5] solution for NaOH [40]. (02)

Earning:   Approval pending.