Gujarat Technological University 2010 B.Pharm Pharmaceutical Chemistry-IV - Question Paper

B. Pharm
Fourth Semester Examination, June 2010
Subject Code - 240003
Pharmaceutical Chemistry-IV

Time: three Hrs. Total Marks: 80
Instructions:
1) Attempt any 5 ques..
2) Make suitable assumptions wherever necessary.
3) Figures to the right indicate full marks.

Ques one a) What is aromaticity? Enlist the Electrophilic aromatic substitution reaction with example. (06)
Ques one b) elaborate phenols? How they differ from alcohols? Write a note on Reimer-Tiemann reaction. (05)
Ques one c) What is resolution? discuss the methods for recemic modification in to enantiomers. (05)

Ques two a) explain the preparation and reaction of Diazonium salt. (06)
Ques two b) How cannizaro reaction is differ from aldol condensation? Write a mechanism for aldol condensation. (05)
Ques two c) describe Nucleophilic aromatic substitution reaction. discuss the Benzyne Mechanism. (05)

Ques three a) Write different reactions involved in oxidation and reduction of aldehydes and ketones. (06)
Ques three b) Write a note on Biphenyls and Allens. (05)
Ques three c) discuss Hell Wolhard Zelinsky reaction with mechanism. (05)

Ques four a) explain different preparation of carboxylic acid. (06)
Ques four b) Write a note on stereoselective and stereospecific reaction with example. (05)
Ques four c) What is conjugated system? discuss the Michael addition reaction. (05)

Ques five a) describe conformation. explain the stability and potential energy modifications of all conformation for n-Butane. (06)
Ques five b) explain the conversion of carboxylic acid to their corresponding chloride, esters and amide derivative. (05)
Ques five c) What is polynuclear aromatic compound? explain the reaction of naphthalene. (05)

Ques six a) elaborate arenes? Write a note on Friedel craft alkylation. explain the limitation of it. (06)
Ques six b) Write a note on Hoffmann degradation of amide with mechanism. (05)
Ques six c) Write a note on Green Chemistry. (05)

Ques seven a) discuss the sequences rule to assign conformation. Draw the possible stereoisomer of 2,3-dichlorohexane. (06)
Ques seven b) Write a short note on Microwave synthesis. (05)
Ques seven c) Write the reaction steps for conversion of: (05)
i) Benzoic acid to aniline.
ii) Nitrobenzene to P-nitro aniline.

Earning:   Approval pending.