Gujarat Technological University 2009 B.Pharm Pharmaceutics-II - university paper

B. Pharm (GTU)
2nd Semester Examination, June 2009
Pharmaceutics-II

Time: three Hours Total Marks: 80
Instructions:
1) Attempt any 5 ques..
2) Make suitable assumptions wherever necessary.
3) Figures to the right indicate full marks.

Q.1 a) Comment: Fluid energy mill is suitable for grinding thermolabile materials. (02)
b) Describe colloid mill with working diagram. (04)
c) Describe ball mill with working principle. (05)
d) Describe theories for energy requirement in size reduction. (05)
Q.2 a) Comment: When vegetable drugs are ground and sifted, none must be rejected. (02)
b) Explain angle of repose, Carr's Index and Hausner ratio with significance. (04)
c) Describe Pharmacopoeial standards for sieves. (05)
d) Explain elutriation. define multistage elutriation process. (05)
Q.3 a) Comment: Turbine mixers are suitable for emulsification. (02)
b) Describe the factors affecting powder mixing. (04)
c) Enlist mixers for semisolids. define planetary mixer. (05)
d) Classify liquid mixers. define propeller mixers. (05)
Q.4 a) discuss Co-crystals with examples. (02)
b) Explain nucleation. define factors affecting crystal growth. (04)
c) Describe Mier's theory for supersaturation with limitations. (05)
d) Describe Swenson-Walker crystallizer with diagram. (05)
Q.5 a) discuss Extraction and Manstrum. (02)
b) Discuss methods of solvent recovery in extraction process. (04)
c) Describe Soxhlet apparatus for extraction. (05)
d) Calculate the % crystal yield of glauber salt (Na2SO4.10H2O) if a pure 32% solution is cooled to 20?C without any evaporative loss. (Solubility of glauber salt is 19.4gm/100gm water). (05)
Q. six a) Differentiate: Compaction and Consolidation. (02)
b) Discuss Heckel and Kawakita's formula w.r.t. compression. (04)
c) Describe various phases of compression for tableting. (05)
d) Describe Direct Compression technology for tablet manufacturing. (05)
Q.7 a) discuss automated process control. explain key elements for the identical. (04)
b) Describe automation for temperature control. (04)
c) Write brief note on fire extinguishers. (04)
d) Describe methods for waste water treatment in pharmaceutical industry.

Earning:   Approval pending.