Gujarat Technological University 2011 B.Pharm Physical Pharmaceutics II - Question Paper
Saturday, 20 July 2013 11:20Web
Seat No.: _____ Enrolment No.______
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Regular / Remedial exam Dec. 2010
Subject code:230001 Subject Name: Physical Pharmaceutics II
Date: 11 /12 /2010 Time: 10.30 am – 01.30 pm
Instructions: Total Marks: 80
1. Attempt any 5 ques..
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) How many ways to express the concentration of solution ? discuss Raoult's legal regulations ? 06
(b) What is number fo equivalents per mole of K3PO4 ? What is equivalent weight of
this salt ? What is equivalent weight of KNO3 ? What is number equivalence per
mole of Ca3(PO4)2 and what is equivalent weight of this salt ?
05
(c) Enlist the colligative properties of solution of Non-Electrolyte. discuss theory of
Van't Hoff formula for osmotic pressure.
05
Q.2 (a) What is Faraday's legal regulations – discuss ? 06
(b) discuss Arrhenius theory of electrolytic dissociation ? 05
(c) What is ionic strength of 0.010 M KCl, 0.010 M BaSO4, and 0.10 M Na2SO4. What
is ionic strength of a solution containing all 3 electrolyte together with Salicylic
acid in 0.010 M concentration in aqueous solution ?
compute mean ionic activity co-efficient for 0.0005 M atropine sulfate (1:2
electrolyte) in aqueous solution containing 0.01 M NaCl at 250 C. Because the
drug is anti-bivalant electrolyte z1z2 = 1x2 = 2. For water at 250 C., A is 0.51
05
Q.3 (a) How the conductance of the solution can be measured – discuss using wheatstone
bridge fro conductance measurement ?
06
(b) How the order of reaction can be determine ? discuss 2nd order of reaction
using suitable example ?
05
(c) describe Shelf life and Half life ? 05
There is saponification of ethyle acetate at 250 C.
CH3COOC2H4 + NaOH CH3COONa + C2H5OH.
The initial concentration of both ethyle acetate and sodium hydroxide in mixture
were 0.01000 M. The change in concentration x of alkali during 20 min. was
0.00566 mole/liter. So (a-x) = 0.01000 – 0.00566 = 0.00434. calculate the Rate
Constant and Half Life of Reaction
Q.4 (a) What is effect of dielectric constant on rate constat ? 06
(b) How Pharmaceutical decomposition affect on stability of drugs. discuss with
example ?
05
(c) Classify the complexes and discuss importance of chelates in metal ion complexes
?
05
Q.5 (a) Which are the factors affecting complexsation and protein binding ? 06
(b) Which are the techniques used to determine the amount of drug bound to protein.
discuss any 1 ?
05
(c) Write the pharmaceutical applications of polymers ? 05
Q. six (a) What is Hydrogels. Classify and discuss its role in drug delivery system ? 06
(b) discuss Fick's legal regulations of Diffusion and what do you mean by steady state ? 05
(c) Which are the factors affecting Diffusion? – discuss them. 05
Q.7 (a) What is Porosity and Tortuosity – discuss in detail ? 06
(b) discuss Higuchi formula (Model) for studying the release of water soluble drugs ? 05
(c) What is role of Dissolution Test in Pharmaceutical Industry ? 05
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