Gujarat Technological University 2011 B.Pharm Pharmaceutical Analysis I - Question Paper

Seat No.: _____ Enrolment No.______
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem-III Regular / Remedial exam Dec. 2010
Subject code: 230004 Subject Name: Pharmaceutical Analysis I
Date: 16 /12 /2010 Time: 10.30 am – 01.30 pm
Instructions: Total Marks: 80
1. Attempt any 5 ques..
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) provide Comment on (Any Three)
1. Water is levelling solvent, while acetic acid is differentiating solvent for
nitric acid, hydrochloric acid and perchloric acid.
2. KI is added in preparation of standard solution of iodine.
3. Organic solvent is added in volhard's method.
4. In the titration of 0.1M NH3 with 0.1 M HCL, Phenolphthalein can be
employed as an indicator.
06
(b) Differentiate subsequent with suitable examples.
1. Lyophobic colloid and lyophillic colloid.
2. Masking and demasking agents.
05
(c) Write a short note on pharmaceutical buffer. 05
Q.2 (a) Write note on solvent, titrant and indicator used for weak acid & weak base
substance in non-aqueous titration.
06
(b) provide the applications of non aqueous titration. 05
(c) explain merits and Demerits of non aqueous titration over aqueous titration. 05
Q.3 (a) What is the effect of pH on the solubility of precipitates? Enlist the end point
detection methods in precipitation titration. discuss fajan's method in detail.
06
(b) What is Co-precipitation? provide kinds of Co-precipitation and note on common
source of co-precipitation.
05
(c) discuss terms
1. Solubility product 2.Post precipitation 3. Titratable acidity
4. Primary standard substance 5. Nucleation
05
Q.4 (a) What is error? Classify the fault and how will you minimize the error? 06
(b) What is analytical method validation? Enlist validation parameters.
Differentiate: (1) Robustness and ruggedness (2) Accuracy and precision
05
(c) provide the importance of quality control and quality assurance in formulation
analysis
05
Q.5 (a) provide the composition of Karl Fischer Reagent. elaborate the limitations of
KFT? Write in detail about end point detection methods in KFT.
06
(b) provide the kinds of redox titration. Enumerate end point detection method for
Redox titration. provide detail about internal indicator method.
05
(c) discuss acid base indicators in detail. 05
2
Q. six (a) Partition coefficient is four in ether/H2O system, compare the efficiency of
extraction of 10 ml aqueous solution of compound with, a) 40 ml portion of
ether b) two times 20 ml portion of ether, c) four times 10 ml portion of ether. provide
the comment.
06
(b) compute titration curve for the titration of 24 ml of 0.2 M n-butyl amine, pKa
10.60 with 0.3 M HCL (titrant). compute pH for 0,2,10,15,16,18 ml.
05
(c) (1) Ksp of Ag2CrO4 is 7.3 X 10-12. compute the molar solubility and solubility
in g/ml. Mol. Wt of Ag2CrO4=337.73.
(2)Calculate the pH of buffer solution prepared by dissolving 242.2 mg of tris
(hydroxyl methyl) amino methane in 10.0 ml of 0.170 M HCl and diluting to
100 ml with water. The molecular weight of solute is 121.1 and the pKa is
8.08 for the conjugated acid.
05
Q.7 (a) provide in detail about chelating agent. Enlist the various kind of complexometric
titration. discuss replacement kind of complexometric titration in detail with
suitable example.
06
(b) Write a short note on counter current extraction. 05
(c) discuss the method for the determination of nitrogen. 05
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