Gujarat Technological University 2010 B.Pharm Pharmaceutics –II - Question Paper

Q.1
(a) describe extraction. define different kinds of extraction. What is the
importance of liquid-liquid extraction in pharmaceutical industry?
08
(b) With a neat and tagged diagram define the Soxhlet extractor for
continuous hot extraction.
04
(c) Write short notes (any one)
1) Process of percolation 2) Dispersed solid leaching
04
Q.2
(a) How can we control crystal size? discuss the construction and
working of Swenson Walker crystallizer.
08
(b) explain caking in crystals and its remedy. 04
(c) What is the importance of crystallization in pharmaceutical
industry?
04
Q.3
(a) explain the factors affecting size reduction. discuss with diagram
construction, working, advantages, limitations and uses of Fluid
Energy Mill.
08
(b) explain the energy requirement in size reduction. 04
(c) A certain crusher accept a feed of rock having a quantity - surface
mean diameter of 0.75 inch and discharge a product of a quantity –
surface mean diameter of 0.20 inch. The power needed to crush 24
tons per hour is 9.3 hp. What should be the power consumption if
the capacity is decreased to 20 tons per hour and quantity – surface
mean diameter of 0.15 inch? Mechanical efficiency remains
unchanged.
04
Q.4
(a) Enumerate different mixers for powder and semisolid mixing.With a
neat and labelled diagram discuss the principle and working of
Planatory Mixer.
08
(b) explain the importance of solid-solid mixing in pharmaceutical
field.
04
(c) discuss the terms: Positive Mixing, Negative Mixing and Neutral
Mixing giving suitable examples.
04
Q.5
(a) Why size separation is required? elaborate the methods involved in
size separation? explain the principle and operation of Cyclone
Separator.
08
(b) define principle and working of Multistage Elutriator. 04
(c) Differentiate Elutriation from Sedimentation. 04
Q. 6
(a) With suitable examples define application of automatic process
control in Pharmaceutical industries.
06
(b) define briefly the various devices available for measurement of
temperature and pressure
06
(c) explain role of lubricants in manufacture of Compressed Tablets. 04
Q.7
(a) What kinds of Electrical hazards can occur in a Pharma Plant? What
precautions should be taken to prevent these kinds of hazards?
06
(b) explain different powder properties that influence its compaction
behavior.
04
(c) Write short notes : (any two)
(1)Colloidal Mill (2)Critical speed of Ball Mill (3)Miers theory of
super saturation
06

Earning:   Approval pending.