Gujarat Technological University 2010 B.Pharm Physical Pharmaceutics II - Question Paper

Q.1 (a) Enlist various methods to determine Molecular weight of non electrolytes
solutions. discuss any 1 method in detail.
06
(b) State Raoult's legal regulations. discuss in details about positive and negative deviations
from Raoult's legal regulations.
05
(c) describe Molality and Normality. elaborate colligative properties? State the
Henry's legal regulations.
05
Q.2 (a) discuss the theory of strong electrolytes. 06
(b) describe electric current. discuss electrolysis in an electrolytic cell. 05
(c) define the Arrhenius's theory of electrolytic dissociation. 05
Q.3 (a) Derive the formula for the 2nd order of reaction (a = b and a ?b). 06
(b) Enlist various factors affect the rate of reaction. explain in details the
effect of temperature on it.
05
(c) Write a short note on Accelerated stability study. 05
Q.4 (a) Derive the formula for protein binding to draw Scatchard plot with its
limitations.
06
(b) Write a short note on chelates and polymer complexes. 05
(c) elaborate various methods to determine the order of a reaction? explain the
half life method in detail.
05
Q.5 (a) what are the various applications of polymers in pharmaceutical field. 06
(b) How to characterize polymers? discuss with various methods. 05
(c) Enlist any 2 synthetic polymers. explain any 2 general properties of
polymer solutions.
05
Q. six (a) discuss in details "Noyes-Whitney" formula for dissolution. 06
(b) What is flux? discuss Fick's 1st legal regulations of diffusion. 05
(c) What is dissolution? discuss dissolution apparatus as per USP method I. 05
Q.7 (a) Comment on
i) Expiry date and shelf life is identical.
ii) Dissolution rate is increased with increase the rate of stirring.
iii) Diffusion across the membrane depends on concentration of drug.
06
(b) CH3COOC2H5 + NaOH ? CH3COONa + C2H5OH
The initial concentrations of both the substances in the mixture= 0.02 M.
The change in concentration of alkali during 20 min. = 0.000283 mole/liter.
Calculate
i) Rate constant and ii) t1/2 of the reaction.
05
(c) Write a short note on Diffusion Cells. 05

Earning:   Approval pending.