Gujarat Technological University 2010 B.Pharm Pharmaceutical Engineering II - Question Paper

Q.1 (a) discuss techniques used for improvement of powder flow. 06
(b) describe content uniformity. provide significance of content uniformity
in pharmacy field.
05
(c) What is control chart?
In the quality control, 1000 tablets were inspected for weight
variation and 2.5% were obtained out of limit range. elaborate the
upper and lower 3s limits for this?
05
Q.2 (a) explain in detail about factors affecting quality of pellet in
Extrusion-Spheronization.
06
(b) Enlist methods used for measurement of powder flow. discuss BP
recommended procedure for density measurement.
05
(c) Write a note on sampling techniques for content uniformity test. 05
Q.3 (a) Enlist application of SCF. explain in detail about pharmaceutical
application.
06
(b) define weight uniformity % deviation limit as per IP 2007.
Cefadroxil tablets were prepared every containing 500 mg of
Cefadroxil. The prepared tablets were evaluated for weight
uniformity test. obtain out whether tablets full fill the requirement of
IP 2007 or not? Data of individual weight (mg) of tablets are as
follows.
1. 617 2. 625 3. 624 4. 616 5. 632 6. 615 7. 628
8. 630 9. 626 10. 619 11. 633 12. 606 13. 636 14. 640
15. 625 16. 621 17. 633 18. 626 19. 622 20. 618
05
(c) discuss direct methods for powder flow measurement. 05
Q.4 (a) define terms arching and rat holing.
Lactose granules was prepared by wet granulation method and
evaluated for compressibility and flow property. Data of valuation
parameters of 10 gm granules are as follow.
Bulk quantity : 48 cc Tapped volume: 42 cc
Heap height : three cm Heap diameter : 11.5 cm
compute Hausner ratio, Carr's index and angle of repose of
granules and provide your comment.
06
(b) Enlist control charts for attributes and discuss c chart. 05
(c) Write a note on Rotary cylinder extruder. 05
Q.5 (a) Write a note on particles from gas-saturated solution. 06
(b) describe critical orifice diameter. define flow through an orifice
method.
05
(c) explain content uniformity acceptance criteria as per BP. 05
Q. six (a) define different methods used for measurement of angle of repose. 06
(b) Draw schematic diagram of control chart and define elements of
control chart.
05
(c) discuss cryopelletization. 05
Q.7 (a) describe HME and discuss its significance in Pharmaceutical
Industry.
06
(b) provide significance of SCF in particle engineering and discuss RESS
technology.
05
(c) Write a note on interpretation of control charts 05

Earning:   Approval pending.