Gujarat Technological University 2010 B.Pharm Pathophysiology - Question Paper

Q.1 (a) discuss the cellular and molecular mechanism of reversible and
irreversible cell injury due to hypoxia/ischaemia.
06
(b) describe apoptosis. define causes, molecular mechanism and
importance of apoptosis.
06
(c) describe and classify amyloidosis. Write a note on localised amyloidosis 04
Q.2 (a) Enumerate cell and plasma derived inflammatory mediators. define
the role of various systems in generation of plasma derived mediators
06
(b) Enlist the different inflammatory cells and explain their role in
inflammation.
06
(c) explain in detail about wound healing process. 04
Q.3 (a) explain the pathogenesis, clinical manifestations and diagnosis of
AIDS.
06
(b) explain the etiology and pathogenesis of B-cell mediated
hypersensitivity reactions with suitable examples.
06
(c) discuss the role of cyclin/cdks in cell proliferation. 04
Q.4 (a) describe autoimmunity and classify autoimmune disease. Write a note on
SLE.
06
(b) explain the cells of immune system and their function. 06
(c) describe and classify cellular adaptations. Write the causes of atrophy and
hyperplasia.
04
Q.5 (a) Classify environmental and nutritional disease. Write a note on
nutritional disease.
06
(b) explain the role of cytokines and free radicals in various phase of
inflammation.
06
(c) define the principles of transplantation and mechanism of allograft
rejection.
04
Q. six Write Short Notes of the following: (Any Four) 16
a) Biological effects of radiation
b) Vascular events in acute inflammation
c) Extracellular matrix
d) HLA system and its importance
e) Carbon monoxide poisoning
Q.7 Differentiate the following: 16
a) Apoptosis and Necrosis
b) Dystrophic and Metastatic calcification
c) Chemotaxis and Phagocytosis
d) Acute and Chronic inflammation

Earning:   Approval pending.