Gujarat Technological University 2010-5th Sem B.Pharm BPharmacy Pharmaceutical chemistry-VI (Medicinal) - Question Paper

Seat No.: _____ Enrolment No.______
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Sem- Vth exam December 2010
Subject code: 250004
Subject Name: Pharmaceutical chemistry-VI (Medicinal)
Date: 13 /12 /2010 Time: 02.30 pm – 05.30 pm
Instructions: Total Marks: 80
1. Attempt any 5 ques..
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Enlist different physicochemical parameters. What is importance of geometrical
and optical isomers for biological action of drug?
06
(b) What is isosterism and bioisosterism? Classify them and provide their latest
application.
05
(c) Write a note on (i) Protein binding of drug
(ii) Partition coefficient
05
Q.2 (a) elaborate heterocyclic compounds? provide the preparations and properties of Furan. 06
(b) discuss the subsequent statements (Any three)
(i) Pyridine is stronger base than aniline
(ii) Furan is less aromatic than Thiophene
(iii) Electrophilic substitution takes place at 2-position in Pyrrole
(iv) Pyrrole cannot be titrated using conc. nitric acid
05
(c) provide the synthesis and reactions of pyrimidine and isoquinoline 05
Q.3 (a) Classify the drug acting on respiratory tract with chemical structure from every
class
06
(b) Write a note on (i) Antiasthmetics (ii) Mucolytic agents 05
(c) Write a note on radio contrast media 05
Q.4 (a) elaborate gastrointestinal agents. Classify them with examples. 06
(b) Write a note on (i) Proton pump inhibitors (ii) Prokinetic agents 05
(c) provide synthesis of Ranitidine and Diphenoxylate 05
Q.5 (a) elaborate autocoids? Enlist different histaminic receptors. Classify H1-antagonist
with examples.
06
(b) explain SAR of antihistamines 05
(c) provide the synthesis of Chlorpheniramine and Citrizine. 05
Q. six (a) provide subsequent synthesis with reaction mechanism (Any two)
(i) Skraup synthesis
(ii) Hantzsch pyridine synthesis
(iii) Fischer-Indole synthesis
06
(b) What is difference ranging from antacids & antisecretary agents? Write a note on
antisecretary agents.
05
(c) elaborate eicossanoids? provide examples of different eicossanoids. Write a note on
prostaglandines.
05
Q.7 (a) Write a note on Ferguson's principle 06
(b) provide any 2 synthesis and any 2 reactions of Imidazole & Thiazole. 05
(c) Write a note on expectorants & antitussive agents 05
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