Gujarat Technological University 2010 B.Pharm , BPharma, 240003 - Pharmaceutical Chemistry for - Question Paper
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Semester IV exam June 2010
Subject code: 240003
Subject Name: Pharmaceutical Chemistry - IV
Date: 15 / 06 / 2010 Time: 10.30 am – 01.30 pm
Total Marks: 80
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Semester- IV Examination June 2010
Seat No. Enrolment No.
Subject code: 240003 Subject Name: Pharmaceutical Chemistry-IV 15 / 06 / 2010 Time: 10.30 am - 01.30 pm
Date:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) What is aromaticity? Enlist the Electrophilic aromatic substitution reaction 06 with example.
(b) What are phenols? How they differ from alcohols? Write a note on Reimer- 05 Tiemann reaction.
(c) What is resolution? Explain the methods for recemic modification in to 05 enantiomers.
Total Marks: 80
Discuss the preparation and reaction of Diazonium salt. 06
Q.2
(a)
(b)
(c)
How cannizaro reaction is differ from aldol condensation? Write a 05 mechanism for aldol condensation.
Define Nucleophilic aromatic substitution reaction. 05 Explain the Benzyne Mechanism.
Q.3 (a)
(b)
(c)
Write various reactions involved in oxidation and reduction of aldehydes 06 and ketones.
Write a note on Biphenyls and Allens. 05
Explain Hell Wolhard Zelinsky reaction with mechanism. 05
Q.4
Discuss various preparation of carboxylic acid. 06
(a)
(b) (c)
(a)
(b) (c)
Write a note on stereoselective and stereospecific reaction with example. 05
What is conjugated system?Explain the michael addition reaction 05
Q.5
Define conformation. Discuss the stability and potential energy changes of 06 all conformation for n-Butane.
Discuss the conversion of carboxylic acid to their corresponding chloride, 05 esters and amide derivative.
What is polynuclear aromatic compound? 05 Discuss the reaction of naphthalene.
Q. 6 (a)
(b)
(c)
Q.7 (a)
(b)
(c)
What are arenes? Write a note on Friedel craft alkylation. Discuss the 06 limitation of it.
Write a note on Hoffmann degradation of amide with mechanism. 05
Write a note on Green Chemistry. 05
Explain the sequences rule to assign conformation. Draw the possible 06 stereoisomer of 2,3-dichlorohexane.
Write a short note on Microwave synthesis. 05
Write the reaction steps for conversion of 05 i) Benzoic acid to aniline ii) Nitrobenzene to P-nitro aniline.
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