Gujarat Technological University 2010 B.Pharm , BPharma, 240004 - Pharmaceutical Analysis for - Question Paper
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Semester IV exam June 2010
Subject code: 240004
Subject Name: Pharmaceutical Analysis II
Date: 18 / 06 /2010 Time: 10.30 am – 01.30 pm
Total Marks: 80
Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharmacy Semester- IV Examination June 2010
Subject code: 240004 Subject Name: Pharmaceutical Analysis- II Date: 18 / 06 /2010 Time: 10.30 am - 01.30 pm
Instructions: Total Marks: 80
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Define and classify chromatography giving suitable examples. 05
(b) What are the retention mechanisms involved in chromatography? Explain any two 06 mechanisms in detail.
(c) What are the advantages of TLC over paper chromatography? Discuss the Pharmacopoeial 05 applications of column chromatography.
Q.2 (a) Describe the different theories of chromatography. 06
(i)Standard reduction potential (ii) equivalent conductance
(iii) Stripping voltametry (iv) Anodic polarographic wave (v) Pulse polarography
(c) Draw a neat and well-labelled diagram of reference electrode. If the specific conductance 05 of 0.01N HCl (36.5) is 0.00792 mho. What is its equivalent conductance.
Q.3 (a) Describe the working of dropping mercury electrode. Write a note on applications of 06 polarography.
(b) Discuss biamperometric titrations in detail. 05
(c) Describe in detail the factors affecting conductance. 05
Q.4 (a) Define calorimetry. Enlist the different types of calorimetry. 04
(b) What is the difference between DTA and DSC. State the applications of both the above 06 methods.
(c) Write a note on TGA. 06
Q.5 (a) Draw a neat and labeled diagram of polarimeter and discuss its applications. 06
(b) Describe briefly the working and application of potentiometer. 04
(c) What are the advantages of instrumental analysis over volumetric analysis? Describe the 06 process of validation in instrumental analysis.
Q. 6 (a) Saturated barium sulphate solution has conductance 3.5 S and that of water is 0.46 S in 04 a cell with cell constant 1.1 cm-1. Equi ionic conductance at infinite dilution for A Ba++=64 and A SO4-- =80 S.cm2.calculate solubility in gram equivalence per lit and %w/v.[ Mol.wt of BaSO4 = 234 Da]
(b) How will you determine the pKa value of acetic acid using pH meter. 06
(c) Distinguish the following pairs: 06
(i) Stationary phase and mobile phase
(ii) Diffusion current and residual current
(iii) Optically active compound and optically inactive compound.
Q.7 04
(a) Calculate the water equivalence factor F of Karl Fisher reagent. If a 150 mg sample of sodium tartarate dehydrate [230.1] required 25 ml of K.F.R.
(b) Explain the following statement: 10
(i) Chromatography is a method of separation and not analysis.
(ii) Equivalent conductance decrease with increase in concentration.
(iii) Nitrogen is passed from solution in polarography.
(iv) In the measurement of pH, glass and calomel electrodes are essential.
(c) What is the titer of 0.09N HCl [36.5] solution for NaOH [40]. 02
2
|
Attachment: |
| Earning: Approval pending. |
