Gujarat Technological University 2012-8th Sem B.Pharm BPharm- Summer- , Pharmaceutical Chemistry - Question Paper
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Univesity Name: Gujrat Technological University
Academic Year: 2012
Courses: B.Pharm VIII Semester exam
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Seat No. Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm-Semester-VIII Summer-2012 Examination Subject code: 280003 Subject Name: Pharmaceutical Chemistry- X(Medicinal Chemistry)
Time: 10:30am to 1:30pm Date: 21-05-2012
Total Marks: 80
1. Attempt any five questions.
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2. |
Make suitable assumptions wherever necessary. | ||
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3. |
Figures to the right indicate full marks. | ||
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Q.1 |
(a) |
Classify antihypertensive agent and write a note on P-blockers |
06 |
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(b) |
Outline SAR activity of Cardiac Glycoside |
05 | |
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(c) |
Write a note on QSAR? Describe Physico-Chemical Parameters in details |
05 | |
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Q2 |
(a) |
Define Antiarrythmic drugs. Give a comprehensive account of antiarrythmic agents used as CVS drugs with one example in each category. |
06 |
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(b) |
Outline SAR activity of HMG COA Reductase inhibitors. |
05 | |
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(c) |
Outline synthesis of following (a) Furosemide (b) Captopril |
05 | |
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Q.3 |
(a) |
Define Atherosclerosis and classify Antihyperlipidemic agents and give normal values for LDL, HDL, Triglycerides and Total Cholesterol levels. |
06 |
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(b) |
Write a note on Hansch Linear Free energy Relationship (LFER) model. |
05 | |
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(c) |
Outline SAR activity of Thiazide diuretics. |
05 | |
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Q.4 |
(a) |
How do computer aided Physico-chemical methods helps for drug interaction sequel to drug design |
06 |
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(b) |
Write a note on Angiotensin II receptor antagonist with example |
05 | |
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(c) |
Discuss mode of action of Thiazide and carbonic anhydrase inhibitors. |
05 | |
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Q.5 |
(a) |
Sketch out the process of blood clotting schematically and discuss on the intervention part of anticoagulants. |
06 |
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(b) |
Write a note on organic nitrates. |
05 | |
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(c) |
Give structures of following (a) Hydralazine (c) Acetazolamide (b) Procainamide (d) Spiranolactone |
05 | |
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Q. 6 |
(a) |
Write a note on Antiplatelet agents and Thrombolytic agents. |
06 |
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(b) |
Role of Combinatorial chemistry |
05 | |
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(c) |
Write a note on Plasma expanders |
05 | |
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Q7 |
(a) |
What do you mean by Molecular Modeling? What are two major aspects of molecular modeling? Explain |
06 |
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(b) |
Write a note on Antiobese drugs. |
05 | |
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(c) |
Synthesis of (a) Warfarin (b) Dobutamine |
05 | |
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Attachment: |
| Earning: Approval pending. |
