VELs University 2010-2nd Year M.Pharm Pharmaceutics , ,, First Sem, PHARMACOKINETICS - Question Paper

part A (10*2=20)

ans the subsequent ques..

1. What do you mean by MRT?
2. What do you mean by organ extraction?
3. What is meant by michaelis-menten kinetics?
4. What do you mean by apparent quantity of distribution?
5. Gut wall metabolism. discuss its significance.
6. What do you mean by Therapeutic equivalence?
7. Why bioequivalence studies are carried out on healthy volunteers?
8. What is meant by wash-out period?
9. What do you mean by flip flop model?
10. Give mathematical construction describing steady state drug blood level in case of IV infusion.

part B (5*5=25)

11. What is accumulation factor? discuss in detail.
12. Discuss the merits and limitations of different methods for estimation of elimination rate constant from urinary excretion data.
13. What is GFR? Add a note on significance of GFR in the management of patients with renal diseases.
14. What are methods for enhancing bioavailability of drugs? discuss in detail any one.
15. 'Poor metabolizers may be at risk of adverse effects from usual doses of many drugs'. Justify the above statement citing relevant examples.

part C (2*15=30)

16. What is meant by capacity limited kinetics? discuss the methods for estimation of Km andVmax.
17. Explain different methods of estimation of absorption rate constant for drugs subsequent 1 compartment model. Add a note on relative merits and limitations.

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