Osmania University (OU) 2008-2nd Year B.Pharm B PHARM.II SEMISTER(MAIN) ,IL - Question Paper

Code no:3012
FACULTY OF TECHNOLOGY
bpharm.II year II semester(main)examination,April 2008
PHARMACEUTICAL ORGANIC CHEMISTRY-II
[time:3 hours] [max marks:70]

ans all ques.
all ques. carry equal marks.
1.(a) (i) what is aromaticity?discuss the electrophilic substitution reactions taking suitable examples.[marks 6]
(ii) write the products produced on friedel crafts alkylation of nitrobenzene and toluene [marks 4]
(iii) discuss the rate of reaction takes place in the above reactions.[marks 4]
OR
(b) (i) discuss the relative stability and aromaticity in naphthalene and anthracene.[marks 6]
(ii)write 2 methods of preparation of naphthalene [marks4]
(ii) write the electrophilic substitution reactions in anthracene.[marks 4]


2 (a) (i)explain the subsequent terms with examples:[marks 8]
(1) plane of symmetry
(2) optical activity
(3) enantiomers
(4) meso structures

(ii) discuss D&L configuration with examples.[marks 6]
OR
(b) write notes on:[marks 14]
(i) configuration and confirmation
(ii) cis-trans isomerism.
3 (a) (i) write 3 methods of preparation of pyridine.[marks 6]
(ii) provide 2 characteristic reactions of pyrrole and fur an[marks 8]
0R
(b)(i) write the structures of 2 compounds representing quinoline and in dole.write their medicinal uses.[marks 6]
(ii) provide 2 synthetic methods for:[marks 8]
(1) isoquinoline. (2) acridine


4 (a) (i) write 2 methods of preparation of pyrazole and oxazole.[marks 6]
(ii) provide 2 characteristic reactions of phenazine and thiazole.[marks 8]
OR
(b) (i) write the 2 structures and their medicinal uses of compounds representing cepham and friazole.[marks 6]
(ii) write the ring structures and nomenclature of:[marks 8]
(1)phenam (2) benzopyran
(3)cinnoloine (4)benzimidazole

5 (a) write the synthetic applications of every of the following:[marks 14]
(1) lithium aluminium hydride (2) lead tetra acetate
(3) n bromosuccinimide (4) selenium oxide
OR
(b) (i) discuss the mechanism of:[marks 6]
(1) beckmann rearrangement
(2) fries migration
(ii) write shirt notes on:[marks 8]
(1) Hoffman's hypobromite reaction
(2) arndt-eistert synthesis

Earning:   Approval pending.