Osmania University (OU) 2009-2nd Year B.Pharm B PHARM II SEMESTER(MAIN),IL/ (pharmaceutical organic chemistry) - Question Paper

FACUTLY OF TECHNOLOGY
b pharm II year II semester (main) examination,April/may 2009
PHARMACEUTICAL ORGANI CHEMISTRY-II
time: three hours max marks:70
ans all ques.
all ques. carry equal marks.

1 (a) (i) what is huckel's rule? write the mechanism involved in sulfonation and friedel crafts acylation of benzene.[marks 6]
(ii) discuss how phenols are acidic and write 3 chemical reactions of phenols.[marks 8]
OR
(b) (i) explain the electrophilic substitution reactions in naphthalene,[marks 5]
(ii) write the products found on oxidation and reduction of naphthalene.[marks 5]
(iii) discuss the theory of orientation and reactivity in mono substituted benzene's with examples.[marks 8]



2 (a) distinguish ranging from the subsequent terms with examples. [marks 8]
(i) absolute and relative configuration
9ii) enantiomer and diastereomer
(iii) chirality and achirality
(iv) meso compound and race mic mixture
(v) discuss cis trans isomerism with examples[marks 6]
OR
(b) (i) write the sequence rules of R and S configuration[marks 6]
(ii) explain the concept of stereo specificity with examples[marks 8]



3 (a) (i) write the structures,numbering and aromaticity of fur an,pyrrole,thiophene and pyridine.[marks 8]
(ii) write 3 methods of preparation of quinoline[marks 6]
OR
(b) (i) write 2 medicinally important compounds containing indole molecule and mention their uses. write 2 methods of preparations of indole[marks 8]
(ii) write the chemical reactions of isoquinoline and acridine[marks 6]



4 (a) (i) write the 2 characteristics reactions of isoxazole and thiazole.[marks 8]
(ii) outline 1 method of synthesis of (A pyrimidine (B) phenothiazine (C) pyrazine (D) diazine[marks 6]
OR
(b) write the structures of 2 medicinally important compounds representing every of the triazole and benzimidazole and their uses.[marks 8]
(ii) explain the method of preparation and characteristics reactions of imidazole.[marks 6]



5 (a) (i) write 2 synthetic applications of every of the following:{marks 6]
(A) NBS (B) sodium period ate (C) selenium oxide
(ii) discuss the mechanism of [marks 8]
(A) beckmann rearrangement (B) fries rearrangement
OR
(i) write a short notes on:[marks 14]
(i) birch reduction
(ii)oppenauer oxidation
(iii) MPV reduction
(iv) arndt-eistert synthesis
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Earning:   Approval pending.