Osmania University (OU) 2008-1st Year B.Pharm B PAHRM II SEMESTER(MAIN) /-(pharmaceutical analysis) - Question Paper

code no 1009
FACULTY OF TECHNOLOGY
B pharmacy II year I semester (main) exam
November/December 2008
PHARMACEUTICAL ANALYSIS-I(chemical analysis)
time: 3hours max marks :70
ans all ques.
all ques. carry equal marks

1 (a) (i) what is precision,accuracy and doubtful value?[marks 4]
(ii) discuss the calibration of volumetric flask[marks 4]
(ii) a series of data of titre values in an estimation of drug is provided as follows: [marks 6]
4.1 , 4.4 , 4.0
4.3 , 4.2 , 4.7
4.9 , 4.6 , 4.4
compute the range and standard deviation
OR
(b) (i) discuss direct titration, back titration and blank titration [marks 4]
(ii) describe equivalent weight .how do you compute the equivalent weight of K2Cr2O7,H2SO4 and Na2CO3. [marks 4]
(iii) elaborate primary standard and secondary standard substances? mention few examples of each[marks 6]


2 (a) (i) expalin bronsted lo wry and Lewis electronic theory[marks 4]
(ii) what is solubility product? write its applications.[marks 5]
(iii) write a note on hydrolysis of salts giving 1 example.[marks 5]
OR
(b)write short notes on:[marks 14]
(i) common ion effect
(ii) buffers
(iii) theory of neutralization indicators


3 (a) (i) discuss the principles of gravimetric analysis[marks 5]
(ii) write the principles of volhard's method[marks 4]
(iii) how do you prepare 250 ml of 0.05N iodine solution and standardize it?[marks 5]
OR
(b) (i) write about absorption indicators.[marks 5]
(ii) write note on iodometry[marks 5]
(iii) write the preparation and standardization of 500 ml of 0.1N NH4SCN solution [marks 4]


4 (a) (i) explain the theory and applications of complexometry.[marks 8]
(ii) write a note on masking and demasking[marks 6]
OR
(b) (i) discuss the principle procedure and apparatus used it the assay of oxygen[marks 7]
(ii) classify the solvents used it non aqueous titrations[marks 3]
(iii) write the applications of Non aqueous titrations[marks 4]


5 (a) (i) describe stoichiometry and mole[marks 4]
(ii) how many molecules of glucose are current in 5.23 gm of glucose (Mwt of glucose 180 amu)[marks 6]
(iii) compute the percentage composition of elements in K2Cr2O7(atomic weights of K,Cr and O are 39,52,16 respectively)[marks 4]
OR
(b) (i) describe empirical and molecular formula.[marks 4]
(ii) write the mass balance equations for the following:[marks 4]
(A) CaCO3 + HCl -> CaCl2 + H2O + CO2
(B) KI + H2SO4 -> KHSO4 + I2 + SO2
(iii) chemical analysis of carbon compound gave 10.06% carbon, 0.84% Hydrogen and 89.10% Chlorine.Calculate the empirical formula of the compound. [marks 6]

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Earning:   Approval pending.