Osmania University (OU) 2009-1st Year B.Pharm Pharmaceutical Organic Chemistry 2nd st Semester Main - Question Paper

1. a) i) discuss the addition of hydrogen halide and hydration in presence of mercuric acetate to alkenes by Markovnikovv's and anti-Markovnilovv's rules
ii) Write a note on cis-trans reduction and acidity of 1-alkynes

OR

b) i) Write a note on Baeyer's strain theory
ii) describe the terms configuration and conformation. Write the different conformations of cyclohexane and explain their stability


2. a) discuss the subsequent with suitable examples:
i) Mesomeric effect
ii) Isomerism (Structural and Spatial)
iii) Resonance
iv) Hybrid orbitals

OR

b) i) What is energy of activation? discuss the energy diagram during the progress of the reaction giving suitable examples.
ii) Write a note on:
A) Tautomerism
B) Molecular Orbital Theory

3. a) discuss the kinetics, mechanics, stereochemistry and factors affecting the nucleophilic substitution reactions

OR

b) i) Write the general methods of preparation of alkylhalides
ii) provide the tests to distinguish primary, secondary and tertiary alcohols
iii) Write the Williamson's synthesis of ethers

4. a) i) define any 4 nucleophilic addition reactions of aldehydes and ketones with mechanism
ii) Write any 2 methods for preparation of ketones

OR

b) i) Write a note on the relative acidity of carboxylic acids
ii) explain the reactivity and synthetic applications of malonic ester and acetoacetic ester

5. a) i) Write the tests to distinguish primary, secondary and tertiary amines
ii) define in brief the Hinsberg's method of separation of amines
iii) Write a note on relative basicity of amines

OR

b) i) explain the preparation and synthetic applications of aryl diazonium salts
ii) Write any 2 methods of preparation and acidity of nitroalkanes

Earning:   Approval pending.