Osmania University (OU) 2010-2nd Year B.Pharm 2nd nd sem,pharmaceutical organic chemistry[main]. - exam paper

FACULTY OF TECHNOLOGY
B.PHARM second YEAR second SEM[MAIN]EXAMINATION,JUNE 2010.
PHARMACEUTICAL ORGANIC CHEMISTRY-2.

NOTE ; ans ALL QUESTIOS.ALL ques. CARRY EQUAL MARKS.

1. a] 1.what are polynuclear aromatic compounds?Discuss in detail the reactions of Anthracene. [7m]
2.explain the subsequent statements giving improper examples.
A]Nitrobenzene upon nitration provide meta nitro nitrobenzene.
B]The product of sulfonation of Naphthalene depens on the temperature.

OR

b] 1.Write anote on Nucleophilic substitution in Halo-benzene. [7m]
2.Describe the mechanism of Acylation and nitration of benzene. [7m]

2. a] 1.Explain optical isomerism with examples. [7m]
2.Explain the subsequent terms [7m]
A]plane polarised light,
B]Diosteriomers,
C]Meso structures,
D]Enantiomers.

OR

b] 1.Write a note on conformational isomerism. [6m]
2.Write the sequence rules to determine R and S configuration.[8m]


3. a] 1.Outline the method of preparation & 2 important reactions of the subsequent [10m]
A]Quinoline,
B]Indole.
2.Give 2 examples of medicinally important compounds representing every of the folloing [4m]
heterocyclic systems
A]Furon,
B]Pyrrole.

OR

b] 1.Explain why electrophilic substitution takes place at three position in Pyridine. [4m]
2.Describe any 1 method of preparation of Quinoline and Isoquinoline. [10m]

4. a] 1.Write the characteristic reactions of Imidazole and Thiazole. [6m]
2.Give any 1 method of preparation of [8m]
A]Pyrazine,
B]Phenothiazine,
C]Pyrazole,
D]Pyrimidine.

OR
b] 1.Write the ring structure and nomenclature of subsequent heterocyclic compounds [6m]
A]Oxazine,
B]Cinnoline,
C]Dioxane.
2.Discuss any 2 methods of preparation and reactions of Imidazole. [8m]

5. a] 1.Write 2 applications of every the following; [6m]
A]Lithium aluminium hydride,
B]LTA,
C]Perchloric acid.
2.Describe the mechanism pf subsequent reaction; [8m]
A]Birch reduction,
B]Oppenneur oxidation.

OR
b] 1.write at lowest 2 synthetic reactions every for the subsequent [7m]
A]Selenium oxide,
B]Sodium periodate,
2.Describe the mechanism of subsequent reaction; [7m]
A]MPV reduction,
B]Arnedt-Eister synthesis.

Earning:   Approval pending.