Osmania University (OU) 2011-2nd Sem B.Pharm 4th yr il/ (subject- Pharmacoinformatics) - Question Paper
_ voae No.: 4435
\ v-'
FACULTY OF TECHNOLOGY B. Pharmacy IV Year II Semester (Main) Examination, April/May, 2011
PHARMACOINFORMATICS Time : 3 Hours] [Max. Marks : 70
Answer all questions.
All questions carry equal marks.
1. (a) Write about database concepts, database architecture Codd rules and
normalization of databases.
Or
(b) What is sequence alignment ? Describe in detail about cladistic methods for phylogenetic tree construction ?
2. (a) What are the algorithms used for alignment of proteins and protein family
sequences? What is meant by substitution of similarity matrix ?
Or
(b) Explain the process for developing pipeline in an algorithm using a Bio-PERL script.
3 (a) Explain the role of electronic medication-administration system (bar-code eMAR) with applications.
Or
(b) Write in detail about the evaluation of drug information using verbal and written reports ?
4. (a) Distinguish between BLASTX and BLAST2 and role of position specific scoring
matrix ?
Or
(b) How the bacterial artifical chromosome libraries are useful in genome sequencing ?
5. (a) Write in detail about the shape complementarily and simulation approaches in
drug docking? o -------------------- ~
Or
b) What is the current trend of quantum mechanics in determination of drug
activity? --------
*L\
|
Attachment: |
| Earning: Approval pending. |
