Osmania University (OU) 2011-1st Year B.Pharm acy II Semester (Main) , PHARMACEUTCIAL ANALYSIS-I ( Chemical Analysis) - Question Paper

FACULTY OF PHARMACY

B.Pharmacy II Year I Semester (Main) Examination, December 2011

PHARMACEUTICAL ANALYSIS - I
( Chemical Analysis)

[Time : three Hours] [Max. Marks: 70]

ans all ques..
All ques. carry equal marks.

1. (a) (i) explain about significant figures and rules for calculation of analytical outcomes.( 4+4)
(ii) discuss about methods of expressing concentration. (6)

OR
(b) (i) What is primary standard and secondary standard? Write the idea requirements for a primary standard. (2+4)
(ii) describe the terms accuracy and precision. discuss the difference ranging from them with help of suitable examples. (8)

2. (a) (i) Deiscuss the theories of neutralization indicators. (7)
(ii) discuss about neutralization curve for titration ranging from strong acid and strong base.(7)

OR
(b) (i) describe buffer solution, buffer action and buffer capacity. discuss the role of buffer in pharmaceutical analysis. (3+5)
(ii) explain legal regulations of mass action its significance (6)

3. (a) (i) explain the principle of oxidation -reduction titration and write a note on redox indicators.(4+4)
(ii) discuss the terms co-precipitation and post precipitation. Write the difference ranging from them(6)

OR
(b) (i) discuss Mohr"s method for determination of chlorides ans write the precaution to be taken in above methods(8)
(ii) explain the different filtering media and devices in gravimetric analysis.(6)

4. (a) (i) explain the principle involved in complexometric titration. discuss about masking and demasking agents.(4+6)
(ii) Write a notes on solvents used in non aqueous titration. (4)

OR
(b) (i) discuss the principle of non aqueous titration. How do you estimate a weakly basic substance by non aqueous method. (4+4)
(ii) Write a note on pM indicators.(6)

5. (a) (i) describe the terms emprical and molecular formula . Write the molecular formula for potassium permanganate, potassium di chromate and write the redox reaction formula of the above 2 compounds with balancing the formula . ( 2+2+6)

(ii) compute the molarity of sulphuric acid when 25ml of 1m sulphuric acid neutralized with 50 ml of decinormal sodium hydroxide. (6)

OR
(b) (i) compute number of moles of sodium carbonate in 500ml of 0.2M sodium carbonate(4)
(ii) describe the terms with equations:
A. Normality
B. Molarity
C. Molality
D. Theoretical yield.
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Earning:   Approval pending.