Jawaharlal Nehru Technological University Hyderabad 2010-2nd Sem M.Pharm Pharmaceutics acy(pharmacuetics)1st sem main s(5 subjects) - Question Paper
( mlr No; SI0*M 10301
JAWAIIAKI.AL NEHRU TECHNOLOCK AI, ITTVIVI.MSI I V HYlhKAHAD M. Pharmacy I Semester Regular Kiuminntl<>uv MnhIi 2010 Modern Pharmaceutical Analytical I n hnl<|iit-
(Comm to Pharmaceutics, Pharmaccutical CherttMrv, 1lmt tiint olnuy ami Hospital
& Clinical Pharmacy)
Time: 3 Mrs M*. Mark*: 60
Answer any Five Question*
All Questions Carry l<'.<|tint Murk*
I What is the principle of separation by paper clmmiiifoj/iiipliy? I pl.im the various development techniques in PC with neat diagram
2.tt) Explain the working principle of GC.
b) Write a note on different types of columns used in (<
3.) Define and classify chromophores with suitable example*
b) hxplain the types of double beam spectrophotomctri with nhcnutie sketches Whai are the advantages of double beam ovtrj single beam instruments
4 What is the principle of FTIR spectroscopy 11 ist the advantages <>! I I IK spectroscopy.
5,i0 Explain the significance of chemical structure in cOiihitiiiK fluorescence with suitable examples, h) What are the factors alTecting fluorescence
6.a) Explain NMR instrumentation with a labeled diagr.un hi W'rite the principle involved in 2D NMR
7 Hxplain the principle and instrumentation ol MS
S.a) What is the principle of DTA. b) Explain the application of ELISA.
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JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD M. Pharmacy I Semester Regular Examinations, March- 2010 Advanced Physical Pharmaceutics (Pharmaceutics)
Time: 3 Hrs Max. Marks: 60
Answer any Five Questions All Questions Carry Equal Marks
1 .a) Differentiate between solid solution and solid dispersion, b) Describe the different methods for the determination of particle size.
2.a) Explain the distribution forces during compaction.
b) Describe the instrumentation to measure these forces with the help of neat diagram.
3.a) Explain the complex order kinetics.
b) Derive the rate equations for zero and first order kinetics.
4.a) Explain the crystal growth phenomena in suspensions and methods to present it.
b) Explain the wetting problem during suspension manufacture and methods to
prevent it.
5. Explain the instrumentation to study the theological properties of disperse systems with help of neat diagrams.
6. Explain the derivatisation and solid state manipulation for the enhancement of solubility
7.a) Explain about solubilization of non electrolytes with relevant equations
b) Write the different coinplexation methods to improve the solubility
8. Describe the various applications of polymers in pharmaceutical formulations.
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JAWAHARLAL NEHRU TECIINOl iH;H Vl I MX |.KM I N HMH RABAD M. Pharmacy I Semester Rcgulat ( NUrvh. April- 2010
Advanced PhartnaocMtK*! twtuwtag* -1 (Ph nro
Time: 3 Hrs M\. Marks: 60
Answer an>
All Questions <'n\ 9 MaiV*
1. Discuss the prime objectives of jmt hmiHiU<K'n \tikic> *hen developing a tablet dosage from. Add a note on of v,*hd 'kite characterization
2. Describe the influence of pH and o** tlrgtifeUtiun ot the active when formulated as oral liquids. Discuss the rcvta*tuc' tv'* ubilns prediction of oral liquids.
3 Discuss the Biopharmaceuttcal w the development ot
pharmaceutical suspensions.
4. DitTerentiate between
(i) Dependent and Independent vaa>abK'
(ii) Bias and random error
5. Enlist various Fluid Bed granuUton xaruMr* IVcnbc v-mous problems encountered in fluid bed granulation
6. W hte short notes on
(a) Extrusion spheronization pi\xw>
(b) Common ion effect
(c) Pro drugs.
7. Discuss briefly the processing prxblem.v that k\*d h* lolloutng problems in tablet manufacture
(d) Capping and lamination
(e) Picking and Sucking
(f) Orange peel effect
(g) Add a note on in - process qualtts c\*uuxl ol tablet*
8. Describe the optimization methods Km of plumuwcutical powders Explain various mixing equipments a\A\UWv to* mull wale and large scale manufacturing of powders.
,IA\N AllARI.AI. NEIIRIJ I M 'IINC)1.(M;IC" AI. UNIVERSITY HVDI RABAD M. Pharmacy I Scmt'Mcr Regular Examinations. March- 2010 Advanced Biotlaliilics & Research Methods (Pharmaceutics. Pharmaceutical Chemistry. Pharmacology. Pharmaceutical Analysis & Quality Assurance, Hospital & Clinical Pharmacy, Quality Assurance) l ime: J llrs Max. Marks: 60
Answer any Else Questions All Questions ( urn Equal Marks
1 Describe in detail about resources Cor research question and methods of literature review.
2. Descnbc the various types of measurement scales and add a short note on reliability and validity of measurements.
3. Write in detail about types of validity and controls used in research.
A Write in detail about any three type* of non-expenmental research.
5. Discuss in detail about the factorial designs in research
(>. Describe in detail about quasi experiments
7 Write a short note on
a. Single subject design
b. Research designs without controls
8. Write in detail about
a. Sampling
b. Survey research methods
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Code No: SI09110303
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
M. Pharmacy I Semester Regular Examinations. March- 2010 Biopharmaceutics & Pharmacokinetics (Pharmaceutics)
Time: 3 Hrs
Max. Marks: 60
Answer any Five Questions All Questions Carr> Equal Marks
1. What are bioavailability and biocquivalcnce studies? Describe their role in evaluation of drugs?
2. What are the formulations factors affecting the bioavailability of tablets, parenterals and liquids?
3. Explain the compartmental models used in Pharmacokinetics? Briefly describe concept of clearance?
4. What are linear and non-linear pharmacokinetic*'' Explain the role of Mechalis-Menten kinetics in non-linear pharmacokinetics?
5. Describe the methods of estimating pharmacokinetic parameters with emphasis on salivery and urinary compartments?
6. Define Chronopharmacokinetics? Explain about physiologically induced time dependency?
7. Describe the kinetics of drug interactions? Explain the drug-drug interactions?
8. Explain the application of compartmental models in absorption of drugs?
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