Rashtrasant Tukadoji Maharaj Nagpur University 2011-1st Year M.Pharm Pharmaceutics Bio and Pharmacokinetics, of Master of Pharmacy, - Question Paper

Paper Code :- P-2
Time :- three Hours
Full Marks :- 80

Solve any 4 questions, Every ques. carries equal marks (20).

Q1. a) What is flip-flop phenomena when is it observed.
b) discuss Wagner-nelson method for determination of absorption rate constant(Ka).
c) Discus the 1 compartment open model for drug administered as continuous I.V. infusion.

Q2. a) How in-vitro and in-vivo correlation is established.
b) What is purpose of bioavailability testing? what are the different methods of assessing bioavailability.

Q3. a) elaborate the causes of non liner kinetics?
b) discuss Michaelis-Menten kinetics and method to determine Km and Vmax.

Q4. a) Discus the biopharmaceutical factors affecting design of controlled release drug delivery.
b) discuss theory of mass transfer in controlled release drug delivery system.

Q5. discuss importance of subsequent pharmacokinetic factors in clinical situations,
1. Dosage regimen design
2. Determination of dose, dose interval and frequency of drug administration
3. Determination of route of administration.

Q6. Write short note on, (any two),
a) Kinetics of protein drug binding
b) Adjustment of dose in renal failure
c) Prodrug in drug targeting.

Earning:   Approval pending.