Amrita Vishwa Vidyapeetham 2011-4th Year B.Pharm school of pharmacy- -il/ - Question Paper

AMRITA VISWAVIDYAPEETHAM UNIVERSITY
AMRITA SCHOOL OF PHARMACY
FOURTH YEAR B.PHARM DEGREE exam -APRIL/MAY 2011
Time: 3hrs
Instructions: Answer part A & part B in separate ans sheets. Draw tagged diagrams wherever necessary
Do not write anything on the ques. paper

CLINICAL PHARMACY & THERAPEUTICS

MULTIPLE option ques. PAPER
1. Which of the subsequent statements regarding ulcerative colitis in not true?
a. Smoking helps to prevent the onset of ulcerative colitis
b. Former smokers are at high risk of developing ulcerative colitis
c. Ulcerative colitis can affect any part of the gut from mouth to the anus
d.NSAID can exacerbate ulcerative colitis.
2 The subsequent laboratory test is most specific for rheumatoid arthritis
a. ESR
B.CRP
C.Anti CCP antibodies
d. RF
3. Which of the subsequent is a 'primary source' of the drug information?
a. Drugs used in pregnancy and lactation Briggs GG
b. USP
c. The Lancet
d. None of the above
4. Therapeutic drug monitoring is most needed for the subsequent drug
a. Digoxin
b. Vancomucin
c. Amikacin
d. Warfarin
5. Which of the subsequent drugs can be considered in a patient who develops cough with the use of enalapril for treatment of hypertension?
a. Lirinopril
b. Fosinopril
c. Telminartan
d. Cilazapril
6. The subsequent medication can precipitate gout in a patient with hyperuricemia
a. Loxartan
b. Enalapril
c. Colchicine
d. Hydrochlorothiazide
7. A patient taking methotrexate should be monitored for the subsequent toxicity other than
a. Hepatotoxicty
b. Ototoxicity
c. Myelosupression
d. Pulmonary toxicity
8. The maximum adult daily dose of acetaminophen in
a.4gm
b.3gm
c.2gm
d.6gm
9. A long acting bronchodilator used in treatment of asthma is
a.Albuterol
b. Formoterol
c. Budesonide
d. Ipratropium bromide
10. In elderly patients taking calcium channel blockers, which of the subsequent macrolides is not assisted with increased risk of hypertension
a. Azithromycin
b. Clarithromycin
c.Erythromycin
d. All the above


part A
Essays: ans any four

1. Classify and explain the different kinds of drug interactions giving clinically relevant examples and their mechanisms
2. explain the pharmacotherapy of hypertension.
3. Distinguish ranging from kind one & kind two diabetes mellitus. explain the role of insulin and oral ant diabetic medications in the pharmacotherapy of diabetes mellitus.
4. What is 'podagra'? Differentiate ranging from gout, pseudo gout and hyperuricemia.Discuss their pathogenesis and pharmacotherapy.
5. What is 'RNTCP' 'DOTS' & 'MDRTB' with respect to TB? explain the pharmacotherapy of TB including the counseling aspects.
6. What is clinical trial? explain the different phases of clinical trials and the guidelines and protocol for conducting clinical trials.

Short Answers: ans any six
1. Discuss the role of pharmacist in promoting patient compliance medication adherence.
2. Discuss principles of drug use in pregnancy
3. Define neonates, infants, and children. explain the factors to be considered and issues encountered in pediatric drug therapy.
4. Give an account of the utility of the pharmacokinetics parameters 'volume of distribution and clearance'.
5. Discuss the different causality assessment methods for evaluating an adverse drug reaction.
6. Mention the different triggers for asthma and counseling of a patient with chronic asthma.
7. Discuss the monitoring parameters and toxicity o disease modifying anti-rheumatic drugs
8. Discuss the complications of liver cirrhosis and their management.

Earning:   Approval pending.